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Literature summary extracted from

  • Jackowski, S.; Fagone, P.
    CTP:phosphocholine cytidylyltransferase: Paving the way from gene to membrane (2005), J. Biol. Chem., 280, 853-856.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.15 Lipids regulation of activity by reversible association with membrane lipids Mus musculus
2.7.7.15 Lipids regulation of activity by reversible association with membrane lipids Homo sapiens
2.7.7.15 Lipids regulation of activity by reversible association with membrane lipids Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.15 ceramide short chain ceramides Homo sapiens
2.7.7.15 ceramide short chain ceramides Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.15 cytoplasm membrane associated Mus musculus 5737
-
2.7.7.15 cytoplasm membrane associated Homo sapiens 5737
-
2.7.7.15 membrane enzyme is activated when bound to vesicles Mus musculus 16020
-
2.7.7.15 membrane enzyme is activated when bound to vesicles Homo sapiens 16020
-
2.7.7.15 membrane enzyme is activated when bound to vesicles Arabidopsis thaliana 16020
-
2.7.7.15 nucleus CCTalpha, CCTbeta is not found in the nucleus Mus musculus 5634
-
2.7.7.15 nucleus CCTalpha, CCTbeta is not found in the nucleus Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.15 CTP + choline phosphate Homo sapiens rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis diphosphate + CDP-choline
-
?
2.7.7.15 CTP + choline phosphate Mus musculus rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, disruption of CCTbeta leads to gonadal dysfunction and reduced fertility diphosphate + CDP-choline
-
?
2.7.7.15 CTP + choline phosphate Arabidopsis thaliana rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, involved in cold acclimation diphosphate + CDP-choline
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Arabidopsis thaliana
-
-
-
2.7.7.15 Homo sapiens
-
-
-
2.7.7.15 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.7.15 phosphoprotein phosphorylation reduces membrane binding and therefore decreases activity Mus musculus
2.7.7.15 phosphoprotein phosphorylation reduces membrane binding and therefore decreases activity Homo sapiens
2.7.7.15 phosphoprotein phosphorylation reduces membrane binding and therefore decreases activity Arabidopsis thaliana

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.15 alveolar cell high expression of enzyme Mus musculus
-
2.7.7.15 alveolar cell high expression of enzyme Homo sapiens
-
2.7.7.15 brain equal expression of CCT alpha and CCT beta Mus musculus
-
2.7.7.15 brain equal expression of CCT alpha and CCT beta Homo sapiens
-
2.7.7.15 additional information CCTalpha expressed in virtually every tissue Mus musculus
-
2.7.7.15 additional information CCTalpha expressed in virtually every tissue Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + choline phosphate
-
Mus musculus diphosphate + CDP-choline
-
?
2.7.7.15 CTP + choline phosphate
-
Homo sapiens diphosphate + CDP-choline
-
?
2.7.7.15 CTP + choline phosphate
-
Arabidopsis thaliana diphosphate + CDP-choline
-
?
2.7.7.15 CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis Homo sapiens diphosphate + CDP-choline
-
?
2.7.7.15 CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, disruption of CCTbeta leads to gonadal dysfunction and reduced fertility Mus musculus diphosphate + CDP-choline
-
?
2.7.7.15 CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine, inhibition of CCT triggers apoptosis, involved in cold acclimation Arabidopsis thaliana diphosphate + CDP-choline
-
?

Subunits

EC Number Subunits Comment Organism
2.7.7.15 dimer
-
Mus musculus
2.7.7.15 dimer
-
Homo sapiens
2.7.7.15 dimer
-
Arabidopsis thaliana

Synonyms

EC Number Synonyms Comment Organism
2.7.7.15 More different isoforms, CCTalpha and CCTbeta 1, -2, and -3 Homo sapiens
2.7.7.15 More different isoforms, CCTalpha and CCTbeta 2 and -3, CCTbeta 1 is not found in mice Mus musculus
2.7.7.15 More two different isoforms Arabidopsis thaliana