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Literature summary extracted from

  • Berger, F.; Lau, C.; Dahlmann, M.; Ziegler, M.
    Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms (2005), J. Biol. Chem., 280, 36334-36341.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.1 epigallocatechin gallate 0.05 mM, 1.4fold activation, NMNAT3 Homo sapiens
2.7.7.1 epigallocatechin gallate 0.05 mM, 10% activation, NMNAT1 Homo sapiens
2.7.7.1 epigallocatechin gallate 0.05 mM, 2.28fold activation, NMNAT2 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.1
-
 Homo sapiens
2.7.7.1 NMNAT1 Homo sapiens
2.7.7.1 NMNAT2 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.1 ADP NMNAT1; NMNAT2 Homo sapiens
2.7.7.1 AMP NMNAT2 Homo sapiens
2.7.7.1 gallotannin IC50: 0.002 mM, NMNAT3; IC50: 0.01 mM; IC50: 0.055 mM, NMNAT2 Homo sapiens
2.7.7.1 NADP+ NMNAT1; NMNAT2 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.1 0.029
-
 ATP NMNAT3 Homo sapiens
2.7.7.1 0.032
-
 nicotinamide ribonucleotide NMNAT2 Homo sapiens
2.7.7.1 0.034
-
 nicotinamide ribonucleotide NMNAT1 Homo sapiens
2.7.7.1 0.04
-
 ATP NMNAT1 Homo sapiens
2.7.7.1 0.059
-
 NAD+ NMNAT1 Homo sapiens
2.7.7.1 0.07
-
 NAD+ NMNAT2 Homo sapiens
2.7.7.1 0.13
-
 NAD+ NMNAT3 Homo sapiens
2.7.7.1 0.204
-
 ATP NMNAT2 Homo sapiens
2.7.7.1 0.209
-
 nicotinamide ribonucleotide NMNAT3 Homo sapiens
2.7.7.1 0.39
-
 diphosphate NMNAT3 Homo sapiens
2.7.7.1 0.937
-
 diphosphate NMNAT1 Homo sapiens
2.7.7.1 1.119
-
 diphosphate NMNAT2 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.1 Golgi apparatus NMNAT2 is assocaiated with Homo sapiens 5794
-
2.7.7.1 mitochondrion NMNAT3 Homo sapiens 5739
-
2.7.7.1 nucleus NMNAT1 is exclusively located in Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide Homo sapiens central enzyme of NAD biosynthetic pathway diphosphate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Homo sapiens Q96T66 isoform NMNAT3
-
2.7.7.1 Homo sapiens Q9BZQ4 isoform NMNAT2
-
2.7.7.1 Homo sapiens Q9HAN9 isoform NMNAT1
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.1
-
 Homo sapiens
2.7.7.1 NMNAT1 Homo sapiens
2.7.7.1 NMNAT2 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.1 brain NMNAT2 Homo sapiens
-
2.7.7.1 heart NMNAT1 Homo sapiens
-
2.7.7.1 kidney NMNAT1 Homo sapiens
-
2.7.7.1 lung NMNAT3 Homo sapiens
-
2.7.7.1 skeletal muscle NMNAT1 Homo sapiens
-
2.7.7.1 spleen NMNAT3 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
2.7.7.1 -80°C, NMNAT2 is stable Homo sapiens
2.7.7.1 4°C, NMNAT1 is stable Homo sapiens
2.7.7.1 4°C, stable Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide central enzyme of NAD biosynthetic pathway Homo sapiens diphosphate + NAD+
-
 ?
2.7.7.1 ATP + nicotinamide ribonucleotide NMNAT1 Homo sapiens diphosphate + NAD+
-
 r
2.7.7.1 ATP + nicotinamide ribonucleotide NMNAT2 Homo sapiens diphosphate + NAD+
-
 r
2.7.7.1 ATP + nicotinamide ribonucleotide NMNAT3 Homo sapiens diphosphate + NAD+
-
 r
2.7.7.1 GTP + nicotinamide ribonucleotide 19% of the activity with GTP, reverse reaction with 57% of the activity with NAD+, NMNA3 Homo sapiens diphosphate + NGD+
-
 r
2.7.7.1 GTP + nicotinamide ribonucleotide 3% of the activity with GTP, reverse reaction with 5% of the activity with NAD+, NMNAT2 Homo sapiens diphosphate + NGD+
-
 r
2.7.7.1 GTP + nicotinamide ribonucleotide 7% of the activity with GTP, reverse reaction with 26% of the activity with NAD+, NMNAT1 Homo sapiens diphosphate + NGD+
-
 r
2.7.7.1 ITP + nicotinamide ribonucleotide 27% of the activity with ATP, NMNAT3 Homo sapiens diphosphate + nicotinamide hypoxanthine dinucleotide
-
 ?
2.7.7.1 ITP + nicotinamide ribonucleotide 5% of the activity with ATP, NMNAT2 Homo sapiens diphosphate + nicotinamide hypoxanthine dinucleotide
-
 ?
2.7.7.1 ITP + nicotinamide ribonucleotide 6% of the activity with ATP, NMNAT1 Homo sapiens diphosphate + nicotinamide hypoxanthine dinucleotide
-
 ?
2.7.7.1 NADH + diphosphate 53% of the activity with NAD+, NMNAT1 Homo sapiens ?
-
 ?
2.7.7.1 NADH + diphosphate 98% of the activity with NAD+, NMNAT2 Homo sapiens ?
-
 ?
2.7.7.1 NADH + diphosphate 99% of the activity with NAD+, NMNAT3 Homo sapiens ?
-
 ?
2.7.7.1 nicotinamide hypoxanthine dinucleotide + diphosphate 98% of the activity with NAD+, NMNAT3 Homo sapiens ?
-
 ?
2.7.7.1 nicotinamide hypoxanthine dinucleotide + diphosphate 37% of the activity with NAD+, NMNAT2 Homo sapiens ITP + nicotinamide ribonucleotide
-
 ?
2.7.7.1 nicotinamide hypoxanthine dinucleotide + diphosphate 55% of the activity with NAD+, NMNAT1 Homo sapiens ITP + nicotinamide ribonucleotide
-
 ?
2.7.7.1 nicotinic acid adenine dinucleotide phosphate + diphosphate 93% of the activity with NAD+, NMNAT1 Homo sapiens ?
-
 ?
2.7.7.1 nicotinic acid adenine dinucleotide phosphate + diphosphate 98% of the activity with NAD+, NMNAT2 Homo sapiens ?
-
 ?
2.7.7.1 nicotinic acid adenine dinucleotide phosphate + diphosphate as active as with NAD+, NMNAT3 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.1 nicotinamide mononucleotide adenylyltransferase
-
 Homo sapiens
2.7.7.1 NMNAT1
-
 Homo sapiens
2.7.7.1 NMNAT2
-
 Homo sapiens
2.7.7.1 NMNAT3
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.7.1 0.002
-
 IC50: 0.002 mM, NMNAT3 Homo sapiens gallotannin
2.7.7.1 0.01
-
 IC50: 0.01 mM Homo sapiens gallotannin
2.7.7.1 0.055
-
 IC50: 0.055 mM, NMNAT2 Homo sapiens gallotannin