Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zhao, X.; Zhuang, S.; Chen, Y.; Boss, G.R.; Pilz, R.B.
    Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3 (2005), J. Biol. Chem., 280, 32683-32692.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.12 cGMP activates both PKGI and PKGII Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.12 expression of PKGI and PKGII in UMR106 cells, PKGI expression enhances the glycosynthase kinase-3 phosphorylation to a greater extent than PKGII Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.1 lithium
-
Rattus norvegicus
2.7.11.1 additional information phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase 3 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.1 Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + C/EBPalpha Rattus norvegicus
-
ADP + phosphorylated C/EBPalpha
-
?
2.7.11.1 ATP + C/EBPbeta Rattus norvegicus
-
ADP + phosphorylated C/EBPbeta
-
?
2.7.11.1 additional information Rattus norvegicus phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis ?
-
?
2.7.11.12 ATP + glycogen synthase kinase-3 Rattus norvegicus phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis ADP + phosphorylated glycogen synthase kinase 3
-
?
2.7.11.12 additional information Rattus norvegicus cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3 ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Rattus norvegicus
-
-
-
2.7.11.12 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.1 phosphoprotein phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase 3 inducing dephosphorylation of C/EBPbeta important in regulation of gene expression during cell proliferation, differentiation, and apoptosis Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.1 osteoblast
-
Rattus norvegicus
-
2.7.11.1 UMR-106 cell primary osteoblast cells Rattus norvegicus
-
2.7.11.12 osteoblast
-
Rattus norvegicus
-
2.7.11.12 UMR-106 cell primary psteoblast cells Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + C/EBPalpha
-
Rattus norvegicus ADP + phosphorylated C/EBPalpha
-
?
2.7.11.1 ATP + C/EBPalpha phosphorylation at consensus sequence (S/T)XXX(S/T) with X representing any amino acid Rattus norvegicus ADP + phosphorylated C/EBPalpha
-
?
2.7.11.1 ATP + C/EBPbeta
-
Rattus norvegicus ADP + phosphorylated C/EBPbeta
-
?
2.7.11.1 ATP + C/EBPbeta phosphorylation at multiple sites, preferably at Thr189 and Ser185, reduced activity with mutants T189A and S185A, mutation of either site appears to impair phosphorylation of neighbouring sites Rattus norvegicus ADP + phosphorylated C/EBPbeta
-
?
2.7.11.1 additional information phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis Rattus norvegicus ?
-
?
2.7.11.12 ATP + glycogen synthase kinase-3 phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis Rattus norvegicus ADP + phosphorylated glycogen synthase kinase 3
-
?
2.7.11.12 ATP + glycogen synthase kinase3 phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3, substrate phosphorylation site mapping Rattus norvegicus ADP + phosphorylated glycogen synthase kinase 3
-
?
2.7.11.12 additional information cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3 Rattus norvegicus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 glycogen synthase kinase-3
-
Rattus norvegicus
2.7.11.1 GSK-3beta
-
Rattus norvegicus
2.7.11.12 PKG
-
Rattus norvegicus
2.7.11.12 PKGI
-
Rattus norvegicus
2.7.11.12 PKGII
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.1 ATP
-
Rattus norvegicus
2.7.11.12 ATP
-
Rattus norvegicus