EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.12 | cGMP | activates both PKGI and PKGII | Rattus norvegicus |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.11.12 | expression of PKGI and PKGII in UMR106 cells, PKGI expression enhances the glycosynthase kinase-3 phosphorylation to a greater extent than PKGII | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.1 | lithium | - |
Rattus norvegicus | |
2.7.11.1 | additional information | phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase 3 | Rattus norvegicus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.1 | Mg2+ | - |
Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.1 | ATP + C/EBPalpha | Rattus norvegicus | - |
ADP + phosphorylated C/EBPalpha | - |
? | |
2.7.11.1 | ATP + C/EBPbeta | Rattus norvegicus | - |
ADP + phosphorylated C/EBPbeta | - |
? | |
2.7.11.1 | additional information | Rattus norvegicus | phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis | ? | - |
? | |
2.7.11.12 | ATP + glycogen synthase kinase-3 | Rattus norvegicus | phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis | ADP + phosphorylated glycogen synthase kinase 3 | - |
? | |
2.7.11.12 | additional information | Rattus norvegicus | cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3 | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.1 | Rattus norvegicus | - |
- |
- |
2.7.11.12 | Rattus norvegicus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.11.1 | phosphoprotein | phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase 3 inducing dephosphorylation of C/EBPbeta important in regulation of gene expression during cell proliferation, differentiation, and apoptosis | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.1 | osteoblast | - |
Rattus norvegicus | - |
2.7.11.1 | UMR-106 cell | primary osteoblast cells | Rattus norvegicus | - |
2.7.11.12 | osteoblast | - |
Rattus norvegicus | - |
2.7.11.12 | UMR-106 cell | primary psteoblast cells | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.1 | ATP + C/EBPalpha | - |
Rattus norvegicus | ADP + phosphorylated C/EBPalpha | - |
? | |
2.7.11.1 | ATP + C/EBPalpha | phosphorylation at consensus sequence (S/T)XXX(S/T) with X representing any amino acid | Rattus norvegicus | ADP + phosphorylated C/EBPalpha | - |
? | |
2.7.11.1 | ATP + C/EBPbeta | - |
Rattus norvegicus | ADP + phosphorylated C/EBPbeta | - |
? | |
2.7.11.1 | ATP + C/EBPbeta | phosphorylation at multiple sites, preferably at Thr189 and Ser185, reduced activity with mutants T189A and S185A, mutation of either site appears to impair phosphorylation of neighbouring sites | Rattus norvegicus | ADP + phosphorylated C/EBPbeta | - |
? | |
2.7.11.1 | additional information | phosphorylation at Ser9 by PKGI and PKGII inhibits the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis | Rattus norvegicus | ? | - |
? | |
2.7.11.12 | ATP + glycogen synthase kinase-3 | phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3 inducing dephosphorylation of C/EBPbeta, i.e. the CCAAT enhancer-binding protein beta, important in regulation of gene expression during cell proliferation, differentiation, and apoptosis | Rattus norvegicus | ADP + phosphorylated glycogen synthase kinase 3 | - |
? | |
2.7.11.12 | ATP + glycogen synthase kinase3 | phosphorylation at Ser9 by PKGI and PKGII inhibiting the glycogen synthase kinase-3, substrate phosphorylation site mapping | Rattus norvegicus | ADP + phosphorylated glycogen synthase kinase 3 | - |
? | |
2.7.11.12 | additional information | cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3 | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.1 | glycogen synthase kinase-3 | - |
Rattus norvegicus |
2.7.11.1 | GSK-3beta | - |
Rattus norvegicus |
2.7.11.12 | PKG | - |
Rattus norvegicus |
2.7.11.12 | PKGI | - |
Rattus norvegicus |
2.7.11.12 | PKGII | - |
Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.1 | ATP | - |
Rattus norvegicus | |
2.7.11.12 | ATP | - |
Rattus norvegicus |