EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.11 | cAMP | dependent on | Homo sapiens | |
2.7.11.11 | additional information | forskolin induces PKA activity | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.11 | H-89 | - |
Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.11 | Mg2+ | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.11 | ATP + claudin-3 | Homo sapiens | high activity in ovarian cancer cells with recombinantly overexpressed claudin-3, phosphorylation of claudin-3 affecting the barrier function with extracellular Ca2+, overview | ADP + phosphorylated claudin-3 | - |
? | |
2.7.11.11 | additional information | Homo sapiens | no activity with claudin-4 | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.11 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.11 | 2008 cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | A-2780 cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | BG-1 cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | CAOV-3 cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | HEY cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | HOSE-B cell | immortilized ovarian surface epithelial cell line | Homo sapiens | - |
2.7.11.11 | IGROV-1 cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | additional information | high PKA activity in ovarian cancer cells | Homo sapiens | - |
2.7.11.11 | OVCA-420 cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | OVCA-429 cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | OVCA-432 cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | OVCA-433 cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | OVCAR-2 cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | OVCAR-3 cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | OVCAR-4 cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | OVCAR-5 cell | ovarian cancer cell line | Homo sapiens | - |
2.7.11.11 | UCI-101 cell | ovarian cancer cell line | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.11 | ATP + claudin-3 | high activity in ovarian cancer cells with recombinantly overexpressed claudin-3, phosphorylation of claudin-3 affecting the barrier function with extracellular Ca2+, overview | Homo sapiens | ADP + phosphorylated claudin-3 | - |
? | |
2.7.11.11 | ATP + claudin-3 | recombinant GST-fusion claudin-3 expressed in Escherichia coli, phosphorylation at Thr192, activity of catalytic PKA subunit | Homo sapiens | ADP + phosphorylated claudin-3 | - |
? | |
2.7.11.11 | ATP + claudin-3 S199A | recombinant GST-fusion claudin-3 mutant S199A expressed in Escherichia coli, phosphorylation at Thr192, activity of catalytic PKA subunit is lower compared to wild-type claudin-3 | Homo sapiens | ADP + phosphorylated claudin-3 S199A | - |
? | |
2.7.11.11 | additional information | no activity with claudin-4 | Homo sapiens | ? | - |
? | |
2.7.11.11 | additional information | no activity with claudin-4, poor activity with claudin-3 mutant T192A | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.11 | PKA | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.11.11 | 30 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.11.11 | 7.5 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.11 | ATP | - |
Homo sapiens |