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Literature summary extracted from

  • Nagaike, T.; Suzuki, T.; Katoh, T.; Ueda, T.
    Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase (2005), J. Biol. Chem., 280, 19721-19727.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.19 expression in Escherichia coli Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.19 additional information hmtPAP knockdown mutant cells show decreased steady state levels of mtDNA-encoded proteins as well as deficient mitochondrial activities such as oxygen consumption rate Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.8 mitochondrion
-
 Homo sapiens 5739
-
2.7.7.19 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.8 RNAn+1 + phosphate Homo sapiens poly(A) length of human mitochondrial mRNAs is controlled by polyadenylation by poly(A) polymerase and deadenylation by polynucleotide phosphorylase. Polyadenylation is required for stability of mitochondrial mRNAs RNAn + a nucleoside diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.8 Homo sapiens
-
-
-
2.7.7.19 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.19 by BD TALON Resin (zco, clontechClontech) or nickel-nitrilotriacetic acid-agarose (Qiagen) Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.19 HeLa cell
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
2.7.7.19 -70°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.8 RNAn+1 + phosphate poly(A) length of human mitochondrial mRNAs is controlled by polyadenylation by poly(A) polymerase and deadenylation by polynucleotide phosphorylase. Polyadenylation is required for stability of mitochondrial mRNAs Homo sapiens RNAn + a nucleoside diphosphate
-
 ?
2.7.7.19 ATP + RNAn
-
 Homo sapiens diphosphate + RNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.8 polynucleotide phosphorylase
-
 Homo sapiens
2.7.7.19 PAP
-
 Homo sapiens
2.7.7.19 poly(A) polymerase
-
 Homo sapiens