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Literature summary extracted from

  • Bogan, M.J.; Agnes, G.R.; Pio, F.; Cornell, R.B.
    Interdomain and membrane interactions of CTP:phosphocholine cytidylyltransferase revealed via limited proteolysis and mass spectrometry (2005), J. Biol. Chem., 280, 19613-19624.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.15 Lipids regulation of activity by reversible association with membranes containing anionic lipids Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.15 expressed in insect cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.15 membrane enzyme is activated when bound to vesicles Rattus norvegicus 16020
-
2.7.7.15 soluble CCTalpha Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.15 41724
-
 2 * 41724, calculated from the deduced amino acid sequence, 2 * 42211, mass spectrometry, phosphorylated protein Rattus norvegicus
2.7.7.15 42211
-
 2 * 41724, calculated from the deduced amino acid sequence, 2 * 42211, mass spectrometry, phosphorylated protein Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.15 CTP + choline phosphate Rattus norvegicus rate limiting enzyme for the synthesis of phosphatidylcholine diphosphate + CDP-choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.15 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.7.15 phosphoprotein
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.15 CTP + choline phosphate
-
 Rattus norvegicus diphosphate + CDP-choline
-
 ?
2.7.7.15 CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine Rattus norvegicus diphosphate + CDP-choline
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.15 dimer 2 * 41724, calculated from the deduced amino acid sequence, 2 * 42211, mass spectrometry, phosphorylated protein Rattus norvegicus