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Literature summary extracted from

  • Viste, K.; Kopperud, R.K.; Christensen, A.E.; Doskeland, S.O.
    Substrate enhances the sensitivity of type I protein kinase a to cAMP (2005), J. Biol. Chem., 280, 13279-13284.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP dependent on, competitive to regulatory subunit RIalpha, at low concentration the activation of PKA type I, but not of PKA type II, by cAMP is accelerated by the peptide or protein substrate by increased dissociation of subunits Calpha and RIalpha, cAMP has low effect on RII/PKA type II, overview Homo sapiens
2.7.11.11 cAMP dependent on, competitive to regulatory subunit RIalpha, at low concentration the activation of PKA type I, but not of PKA type II, by cAMP is accelerated by the peptide or protein substrate by increased dissociation of subunits Calpha and RIalpha, cAMP has low effect on RII/PKA type II, overview Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.11 additional information the regulatory subunits competitively inhibit the PKA kinase activity Bos taurus
2.7.11.11 additional information the regulatory subunits competitively inhibit the PKA kinase activity Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Homo sapiens
2.7.11.11 Mg2+
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Bos taurus
-
 bovine catalytic subunit C and human regulatory subunits RI and RII
-
2.7.11.11 Homo sapiens
-
 bovine catalytic subunit C and human regulatory subunits RI and RII
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 heart
-
 Homo sapiens
-
2.7.11.11 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + Kemptide activity of catalytic PKA subunit Homo sapiens ADP + phosphorylated Kemptide
-
 ?
2.7.11.11 ATP + Kemptide activity of catalytic PKA subunit Bos taurus ADP + phosphorylated Kemptide
-
 ?
2.7.11.11 ATP + tyrosine hydroxylase activity of catalytic PKA subunit Homo sapiens ADP + phosphorylated tyrosine hydroxylase
-
 ?
2.7.11.11 ATP + tyrosine hydroxylase activity of catalytic PKA subunit Bos taurus ADP + phosphorylated tyrosine hydroxylase
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 type I protein kinase A
-
 Homo sapiens
2.7.11.11 type I protein kinase A
-
 Bos taurus
2.7.11.11 type II protein kinase A
-
 Homo sapiens
2.7.11.11 type II protein kinase A
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Homo sapiens
2.7.11.11 ATP
-
 Bos taurus