EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.11 | cAMP | dependent on, competitive to regulatory subunit RIalpha, at low concentration the activation of PKA type I, but not of PKA type II, by cAMP is accelerated by the peptide or protein substrate by increased dissociation of subunits Calpha and RIalpha, cAMP has low effect on RII/PKA type II, overview | Homo sapiens | |
2.7.11.11 | cAMP | dependent on, competitive to regulatory subunit RIalpha, at low concentration the activation of PKA type I, but not of PKA type II, by cAMP is accelerated by the peptide or protein substrate by increased dissociation of subunits Calpha and RIalpha, cAMP has low effect on RII/PKA type II, overview | Bos taurus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.11 | additional information | the regulatory subunits competitively inhibit the PKA kinase activity | Bos taurus | |
2.7.11.11 | additional information | the regulatory subunits competitively inhibit the PKA kinase activity | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.11 | Mg2+ | - |
Homo sapiens | |
2.7.11.11 | Mg2+ | - |
Bos taurus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.11.11 | Bos taurus | - |
bovine catalytic subunit C and human regulatory subunits RI and RII | - |
2.7.11.11 | Homo sapiens | - |
bovine catalytic subunit C and human regulatory subunits RI and RII | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.11.11 | heart | - |
Homo sapiens | - |
2.7.11.11 | heart | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.11.11 | ATP + Kemptide | activity of catalytic PKA subunit | Homo sapiens | ADP + phosphorylated Kemptide | - |
? | |
2.7.11.11 | ATP + Kemptide | activity of catalytic PKA subunit | Bos taurus | ADP + phosphorylated Kemptide | - |
? | |
2.7.11.11 | ATP + tyrosine hydroxylase | activity of catalytic PKA subunit | Homo sapiens | ADP + phosphorylated tyrosine hydroxylase | - |
? | |
2.7.11.11 | ATP + tyrosine hydroxylase | activity of catalytic PKA subunit | Bos taurus | ADP + phosphorylated tyrosine hydroxylase | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.11.11 | type I protein kinase A | - |
Homo sapiens |
2.7.11.11 | type I protein kinase A | - |
Bos taurus |
2.7.11.11 | type II protein kinase A | - |
Homo sapiens |
2.7.11.11 | type II protein kinase A | - |
Bos taurus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.11.11 | ATP | - |
Homo sapiens | |
2.7.11.11 | ATP | - |
Bos taurus |