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Literature summary extracted from

  • Hernandez, F.; Perez, M.; Lucas, J.J.; Mata, A.M.; Bhat, R.; Avila, J.
    Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease (2004), J. Biol. Chem., 279, 3801-3806.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.1 lithium after inhibition of GSK-3 in cortical neurons, the splicing factor SC35 is nuclearly redistributed and enriched in nuclear speckles and colocalizes with the kinase Homo sapiens
2.7.11.26 lithium after inhibition of GSK-3 in cortical neurons, the splicing factor SC35 is nuclearly redistributed and enriched in nuclear speckles and colocalizes with the kinase Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.1 microtubule
-
 Homo sapiens 5874
-
2.7.11.1 nucleus GSK-3 after cell treatment with lithium Homo sapiens 5634
-
2.7.11.26 microtubule
-
 Homo sapiens 5874
-
2.7.11.26 nucleus GSK-3 after cell treatment with lithium Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.1 Mg2+
-
 Homo sapiens
2.7.11.26 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.1 ATP + SC35 Homo sapiens substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors ADP + phosphorylated SC35
-
 ?
2.7.11.1 ATP + [tau-protein] Homo sapiens
-
 ADP + O-phospho-[tau-protein]
-
 ?
2.7.11.1 additional information Homo sapiens GSK-3 affects the tau-mRNA splicing of exon 10 via phosphorylation of the splicing factors of the serine/arginine-rich splicing factor SR family, e.g. SC35, leading to priming and dislocation of the splicing factor, aberrant tau splicing contributes to tauopathies including Alzheimer's disease, overview ?
-
 ?
2.7.11.26 ATP + SC35 Homo sapiens substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors ADP + phosphorylated SC35
-
 ?
2.7.11.26 ATP + [tau-protein] Homo sapiens
-
 ADP + O-phospho-[tau-protein]
-
 ?
2.7.11.26 additional information Homo sapiens GSK-3 affects the tau-mRNA splicing of exon 10 via phosphorylation of the splicing factors of the serine/arginine-rich splicing factor SR family, e.g. SC35, leading to priming and dislocation of the splicing factor, aberrant tau splicing contributes to tauopathies including Alzheimer's disease, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Homo sapiens
-
-
-
2.7.11.26 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.1 brain
-
 Homo sapiens
-
2.7.11.1 brain cortex
-
 Homo sapiens
-
2.7.11.1 commercial preparation purified recombinant GSK-3beta Homo sapiens
-
2.7.11.1 neuron
-
 Homo sapiens
-
2.7.11.26 brain
-
 Homo sapiens
-
2.7.11.26 brain cortex
-
 Homo sapiens
-
2.7.11.26 commercial preparation purified recombinant GSK-3beta Homo sapiens
-
2.7.11.26 neuron
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.1 additional information
-
-
 Homo sapiens
2.7.11.26 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + RSRSRSRSRSRSPPPVSK SC35-derived peptide 180-197, recombinant GSK-3beta Homo sapiens ADP + phosphorylated RSRSRSRSRSRSPPPVSK
-
 ?
2.7.11.1 ATP + SC35 substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors Homo sapiens ADP + phosphorylated SC35
-
 ?
2.7.11.1 ATP + SC35 substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors, recombinant GSK-3beta Homo sapiens ADP + phosphorylated SC35
-
 ?
2.7.11.1 ATP + [tau-protein]
-
 Homo sapiens ADP + O-phospho-[tau-protein]
-
 ?
2.7.11.1 ATP + [tau-protein] substrate of GSK-3 in brain Homo sapiens ADP + O-phospho-[tau-protein]
-
 ?
2.7.11.1 additional information GSK-3 affects the tau-mRNA splicing of exon 10 via phosphorylation of the splicing factors of the serine/arginine-rich splicing factor SR family, e.g. SC35, leading to priming and dislocation of the splicing factor, aberrant tau splicing contributes to tauopathies including Alzheimer's disease, overview Homo sapiens ?
-
 ?
2.7.11.26 ATP + RSRSRSRSRSRSPPPVSK SC35-derived peptide 180-197, recombinant GSK-3beta Homo sapiens ADP + phosphorylated RSRSRSRSRSRSPPPVSK
-
 ?
2.7.11.26 ATP + SC35 substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors Homo sapiens ADP + phosphorylated SC35
-
 ?
2.7.11.26 ATP + SC35 substrate prephosphorylated SC35, SC35 is a member of the SR family of serine/arginine-rich splicing factors, recombinant GSK-3beta Homo sapiens ADP + phosphorylated SC35
-
 ?
2.7.11.26 ATP + [tau-protein]
-
 Homo sapiens ADP + O-phospho-[tau-protein]
-
 ?
2.7.11.26 additional information GSK-3 affects the tau-mRNA splicing of exon 10 via phosphorylation of the splicing factors of the serine/arginine-rich splicing factor SR family, e.g. SC35, leading to priming and dislocation of the splicing factor, aberrant tau splicing contributes to tauopathies including Alzheimer's disease, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 glycogen synthase kinase-3
-
 Homo sapiens
2.7.11.1 GSK-3
-
 Homo sapiens
2.7.11.1 GSK-3beta
-
 Homo sapiens
2.7.11.1 More see also EC 2.7.11.26 Homo sapiens
2.7.11.26 glycogen synthase kinase-3
-
 Homo sapiens
2.7.11.26 GSK-3
-
 Homo sapiens
2.7.11.26 GSK-3beta
-
 Homo sapiens
2.7.11.26 More see also EC 2.7.11.1 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.1 37
-
 assay at Homo sapiens
2.7.11.26 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.1 7.4
-
 assay at Homo sapiens
2.7.11.26 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.1 ATP
-
 Homo sapiens
2.7.11.26 ATP
-
 Homo sapiens