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Literature summary extracted from

  • Ando, K.; Ozaki, T.; Yamamoto, H.; Furuya, K.; Hosoda, M.; Hayashi, S.; Fukuzawa, M.; Nakagawara, A.
    Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation (2004), J. Biol. Chem., 279, 25549-25561.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.21 expression of FLAG-tagged Plk1 in COS-7 cells, co-expression of Plk1 and p53 in p53-deficient lung carcinoma H1299 cells greatly decreases the p53-mediated recombinant transcription, this effect does not appear with co-expression of kinase-defective K82M Plk1 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.21 K82M site-directed mutagenesis, kinase-defective mutant Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.21 ataxia-telangiectasia mutant i.e. ATM, inhibits p53 phosphorylation by Plk1 in vivo Homo sapiens
2.7.11.21 additional information Plk1 expression is decreased during ciplatin-induced apoptosis while p53 is stabilized Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.21 nucleus the nuclear localization sequence is 48RSRRRYVRGR57 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.21 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.21 ATP + p53 Homo sapiens Plk1 binds tumor suppressor p53, dependent on DNA-binding to the specific DNA binding domain within residues 102-292 of p53, and inhibits its transactivation activity ADP + phosphorylated p53
-
 ?
2.7.11.21 additional information Homo sapiens Plk1 is involved in the regulation of M-phase of the cell cycle and might also be involved in tumorigenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.21 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.21 neuroblastoma cell
-
 Homo sapiens
-
2.7.11.21 SH-SY5Y cell neuroblastoma cell Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.21 ATP + p53 Plk1 binds tumor suppressor p53, dependent on DNA-binding to the specific DNA binding domain within residues 102-292 of p53, and inhibits its transactivation activity Homo sapiens ADP + phosphorylated p53
-
 ?
2.7.11.21 ATP + p53 phosphorylation at Ser20 Homo sapiens ADP + phosphorylated p53
-
 ?
2.7.11.21 additional information Plk1 is involved in the regulation of M-phase of the cell cycle and might also be involved in tumorigenesis Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.21 Plk1
-
 Homo sapiens
2.7.11.21 Polo-like kinase 1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.21 ATP
-
 Homo sapiens