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Literature summary extracted from

  • Alfthan, K.; Heiska, L.; Gronholm, M.; Renkema, G.H.; Carpen, O.
    Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization (2004), J. Biol. Chem., 279, 18559-18566.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP dependent on Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.11 expression of the catalytic subunit C in HEK-293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.11 H-89 selective, but not specific inhibitor of PKA Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 ATP + merlin Homo sapiens recombinant human substrate protein expressed in HEK-293 cells, activity of the catalytic subunit C, phosphorylation at Ser518 induces N-terminal binding of merlin to ezrin ADP + phosphorylated merlin
-
 ?
2.7.11.11 additional information Homo sapiens merlin acts as an PKA-anchoring protein being linked to the cAMP/PKA signaling pathway ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + merlin recombinant human substrate protein expressed in HEK-293 cells, activity of the catalytic subunit C, phosphorylation at Ser518 induces N-terminal binding of merlin to ezrin Homo sapiens ADP + phosphorylated merlin
-
 ?
2.7.11.11 ATP + merlin a membrane/cytoskeleton linker protein, activity of the catalytic subunit C, phosphorylation at the N- and the C-terminus, e.g. at Ser518 Homo sapiens ADP + phosphorylated merlin
-
 ?
2.7.11.11 additional information merlin acts as an PKA-anchoring protein being linked to the cAMP/PKA signaling pathway Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 cyclic AMP-dependent protein kinase
-
 Homo sapiens
2.7.11.11 PKA
-
 Homo sapiens
2.7.11.11 protein kinase A
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.11 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.11 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Homo sapiens