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Literature summary extracted from
- Ceramide kinase is a mediator of calcium-dependent degranulation in mast cells (2004), J. Biol. Chem., 279, 17570-17577.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 2.7.1.138 | stable expression in the cytosol and plasma membrane of rat basophilic leukemia RBL-2H3 cells, overexpression of the enzyme enhances the level of degranulation | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.1.138 | N-acetylsphingosine | i.e. C2-Cer, in vivo during inhibition of mast cell degranulation | Mus musculus |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 2.7.1.138 | cytosol | - |
Mus musculus | 5829 | - |
| 2.7.1.138 | plasma membrane | - |
Mus musculus | 5886 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.1.138 | Ca2+ | optimal activation at 1 mM, enzyme is a mediator of calcium-dependent degranulation in mast cells | Mus musculus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.1.138 | ATP + ceramide | Mus musculus | - |
ADP + ceramide 1-phosphate | - |
? | |
| 2.7.1.138 | additional information | Mus musculus | the enzyme is a mediator of calcium-dependent degranulation in mast cells | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.1.138 | Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.1.138 | ATP + ceramide | - |
Mus musculus | ADP + ceramide 1-phosphate | - |
? | |
| 2.7.1.138 | additional information | the enzyme is a mediator of calcium-dependent degranulation in mast cells | Mus musculus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.7.1.138 | CERK | - |
Mus musculus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 2.7.1.138 | 30 | - |
assay at | Mus musculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.1.138 | ATP | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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