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Literature summary extracted from

  • Temel, R.E.; Gebre, A.K.; Parks, J.S.; Rudel, L.L.
    Compared with acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol (2003), J. Biol. Chem., 278, 47594-47601.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.26 Chlorocebus aethiops
-
 recombinant isoforms ACAT1 and ACAT2
-
2.3.1.43 Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.43 0.402
-
 purified recombinant enzyme, substrate cholesterol Homo sapiens
2.3.1.43 0.42
-
 purified recombinant enzyme, substrate sitosterol Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.26 additional information isoform ACAT2 displays significantly greater selectivity for cholesterol compared with sitosterol than ACAT1 Chlorocebus aethiops ?
-
 ?
2.3.1.26 oleoyl-CoA + cholesterol
-
 Chlorocebus aethiops CoA + cholesteryl oleate
-
 ?
2.3.1.26 oleoyl-CoA + sitosterol
-
 Chlorocebus aethiops CoA + sitosteryl oleate
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol purified recombinant enzyme Homo sapiens 1-acylglycerophosphocholine + cholesteryl ester
-
 ?
2.3.1.43 phosphatidylcholine + sitosterol purified recombinant enzyme Homo sapiens 1-acylglycerophosphocholine + sitosteryl ester
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Homo sapiens
2.3.1.43 lecithin:cholesterol acyltransferase
-
 Homo sapiens