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Literature summary extracted from

  • Sun, Y.; Mochizuki, Y.; Majerus, P.W.
    Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis (2003), J. Biol. Chem., 278, 43645-43653.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.159 expression in HeLa cells and in HEK-293 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.159 additional information enzyme overexpression in HEK-293 cells inhibits TNFalpha-induced activation of caspases-8, -3, and -9, siRNA gene silencing of the enzyme in HeLa cells results in higher susceptibility of the cells to TNFalpha-induced apoptosis Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.159 nucleus
-
 Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.159 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.159 additional information Homo sapiens the enzyme inhibits tumor necrosis factor alpha-induced apoptosis involving the activation of PARP, BID, caspase-3 and caspase-8, but protects not against etoposide- or cycloheximide-induced apotosis, mechanism ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.159 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.159 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.159 ATP + 1D-myo-inositol-1,3,4-trisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
 ?
2.7.1.159 ATP + 1D-myo-inositol-1,3,4-trisphosphate
-
 Homo sapiens ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
 ?
2.7.1.159 additional information the enzyme inhibits tumor necrosis factor alpha-induced apoptosis involving the activation of PARP, BID, caspase-3 and caspase-8, but protects not against etoposide- or cycloheximide-induced apotosis, mechanism Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.159 5/6 kinase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.159 ATP
-
 Homo sapiens