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Literature summary extracted from

  • Wilson, M.P.; Sun, Y.; Cao, L.; Majerus, P.W.
    Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2 (2001), J. Biol. Chem., 276, 40998-41004.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.159 expression in 293 cells, expression in Spodoptera frugiperda Sf21 cells using the baculovirus infection system Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.159 1D-myo-inositol-3,4,5,6-tetrakisphosphate inhibits the 5/6-kinase activities, but not the phosphorylation of ATF-2 Bos taurus
2.7.1.159 Mn2+ activates the protein phopshorylation, but inhibits the inositol-1,3,4-trisphosphate 5/6-kinase reaction Bos taurus
2.7.1.159 protein kinase A slight inhibition of enzyme activity with ATF-2 as substrate Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.159 Mg2+
-
Homo sapiens
2.7.1.159 Mg2+
-
Bos taurus
2.7.1.159 Mn2+ activates the protein phopshorylation, but inhibits the inositol-1,3,4-trisphosphate 5/6-kinase reaction Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.159 ATP + 1D-myo-inositol-1,3,4-trisphosphate Bos taurus
-
ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
?
2.7.1.159 ATP + 1D-myo-inositol-1,3,4-trisphosphate Bos taurus
-
ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
?
2.7.1.159 additional information Bos taurus the enzyme is involved in both the inositol phosphate and the stress response pathways which are linked by the enzyme, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.159 Bos taurus
-
calf
-
2.7.1.159 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.159 partially as COP9 signalosome complex and further as a single protein Bos taurus
2.7.1.159 recombinant enzyme from insect Sf21 cells, recombinant enzyme partially from 293 cells by ion exchange chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.159 brain
-
Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.159 372
-
purified calf brain enzyme, substrate 1D-myo-inositol-1,3,4-trisphosphate Bos taurus
2.7.1.159 500
-
purified recombinant enzyme from Sf21 cells, with substrate 1D-myo-inositol-1,3,4-trisphosphate Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.159 ATP + 1D-myo-inositol-1,3,4-trisphosphate
-
Bos taurus ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
?
2.7.1.159 ATP + 1D-myo-inositol-1,3,4-trisphosphate 5fold lower activity compared to 1D-myo-inositol-1,3,4,6-tetrakisphosphate formation Homo sapiens ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
?
2.7.1.159 ATP + 1D-myo-inositol-1,3,4-trisphosphate 5fold lower activity compared to 1D-myo-inositol-1,3,4,6-tetrakisphosphate formation Bos taurus ADP + 1D-myo-inositol-1,3,4,5-tetrakisphosphate
-
?
2.7.1.159 ATP + 1D-myo-inositol-1,3,4-trisphosphate
-
Bos taurus ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
?
2.7.1.159 ATP + 1D-myo-inositol-1,3,4-trisphosphate 5fold higher activity compared to 1D-myo-inositol-1,3,4,5-tetrakisphosphate formation Homo sapiens ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
?
2.7.1.159 ATP + 1D-myo-inositol-1,3,4-trisphosphate 5fold higher activity compared to 1D-myo-inositol-1,3,4,5-tetrakisphosphate formation Bos taurus ADP + 1D-myo-inositol-1,3,4,6-tetrakisphosphate
-
?
2.7.1.159 ATP + ATF-2 phosphorylation predominantly on serine residues Homo sapiens ADP + phosphorylated ATF-2
-
?
2.7.1.159 ATP + ATF-2 phosphorylation predominantly on serine residues Bos taurus ADP + phosphorylated ATF-2
-
?
2.7.1.159 ATP + c-Jun
-
Homo sapiens ADP + phosphorylated c-Jun
-
?
2.7.1.159 ATP + c-Jun
-
Bos taurus ADP + phosphorylated c-Jun
-
?
2.7.1.159 additional information the enzyme is involved in both the inositol phosphate and the stress response pathways which are linked by the enzyme, overview Bos taurus ?
-
?
2.7.1.159 additional information the enzyme is part of the COP9 signalosome complex consisting of 8 proteins Homo sapiens ?
-
?
2.7.1.159 additional information the enzyme is part of the COP9 signalosome complex consisting of 8 proteins Bos taurus ?
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.159 37
-
assay at Homo sapiens
2.7.1.159 37
-
assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.159 7.5
-
assay at Homo sapiens
2.7.1.159 7.5
-
assay at Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.159 ATP
-
Homo sapiens
2.7.1.159 ATP
-
Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.159 0.00003
-
1D-myo-inositol-3,4,5,6-tetrakisphosphate pH 7.5, 37°C Bos taurus