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Literature summary extracted from

  • Kitagawa, H.; Shimakawa, H.; Sugahara, K.
    The tumor suppressor EXT-like gene EXTL2 encodes an alpha1,4N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glucosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate (1999), J. Biol. Chem., 274, 13933-13937.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.223 Homo sapiens
-
 recombinant enzyme lacking first N-terminal 57 amino acids to give a soluble protein, expression in malignant fibrous histocytoma cell line
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.223 recombinant enzyme lacking first N-terminal 57 amino acids to give a soluble protein, expression in malignant fibrous histiocytoma cell line Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.223 liver fetal liver Homo sapiens
-
2.4.1.223 additional information ubiquitous expression of gene Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.223 additional information no transfer of N-acetylglucosamine to beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser Homo sapiens ?
-
 ?
2.4.1.223 UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser 46% of the rate with beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-naphthalenemethanol Homo sapiens UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-O-Ser
-
 ?
2.4.1.223 UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-naphthalenemethanol
-
 Homo sapiens UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl1-O-naphthalenemethanol
-
 ?
2.4.1.223 UDP-N-acetyl-D-galactosamine + beta-D-glucuronosyl-(1-3)-beta-D-N-acetylgalactosamine
-
 Homo sapiens UDP + alpha-N-acetyl-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-N-acetylgalactosamine
-
 ?
2.4.1.223 UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-O-naphthalenemethanol 28% of the rate with UDP-N-acetyl-D-galactosamine Homo sapiens UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl1-O-naphthalenemethanol
-
 ?