EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.3.2.9 | cyclohexane oxide | - |
Rattus norvegicus | |
3.3.2.9 | additional information | no inhibition by isoquinoline, 7-oxocholesterol, 7-oxocholestanol, and 6-oxocholestanol | Rattus norvegicus | |
3.3.2.11 | 5,6alpha-epoxy-5alpha-cholestan-3beta-ol | competitive to 5,6beta-epoxy-5alpha-cholestan-3beta-ol | Rattus norvegicus | |
3.3.2.11 | 5,6beta-epoxy-5beta-cholestan-3beta-ol | competitive to 5,6alpha-epoxy-5alpha-cholestan-3beta-ol | Rattus norvegicus | |
3.3.2.11 | 6-oxocholestanol | - |
Rattus norvegicus | |
3.3.2.11 | 7-oxocholestanol | - |
Rattus norvegicus | |
3.3.2.11 | 7-oxocholesterol | - |
Rattus norvegicus | |
3.3.2.11 | cholestane-3beta,5alpha,6beta-triol | product inhibition | Rattus norvegicus | |
3.3.2.11 | additional information | no inhibition by isoquinoline, styrene oxide, cyclohexane oxide, benzil, cholesterol, and cholic acid | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.3.2.11 | additional information | - |
additional information | kinetics | Rattus norvegicus | |
3.3.2.11 | 0.0037 | - |
5,6alpha-epoxy-5alpha-cholestan-3beta-ol | pH 7.4, 37°C, versus 5,6beta-epoxy-5alpha-cholestan-3beta-ol | Rattus norvegicus | |
3.3.2.11 | 0.0044 | - |
5,6beta-epoxy-5beta-cholestan-3beta-ol | pH 7.4, 37°C, versus 5,6alpha-epoxy-5alpha-cholestan-3beta-ol | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.3.2.9 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.3.2.11 | 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | Rattus norvegicus | - |
cholestane-3beta,5alpha,6beta-triol | - |
? | |
3.3.2.11 | 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O | Rattus norvegicus | - |
cholestane-3beta,5alpha,6beta-triol | - |
? | |
3.3.2.11 | additional information | Rattus norvegicus | the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9 | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.3.2.9 | Rattus norvegicus | - |
male sprague-dawley rats | - |
3.3.2.11 | Rattus norvegicus | - |
male sprague-dawley rats | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.3.2.11 | partially by microsome preparation | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.3.2.9 | liver | - |
Rattus norvegicus | - |
3.3.2.11 | liver | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
3.3.2.11 | 0.00045 | - |
liver microsomes, substrate 5,6beta-epoxy-5alpha-cholestan-3beta-ol | Rattus norvegicus |
3.3.2.11 | 0.00048 | - |
liver microsomes, substrate 5,6alpha-epoxy-5alpha-cholestan-3beta-ol | Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.3.2.9 | additional information | no activity with 5,6alpha-epoxy-5alpha-cholestan-3beta-ol and 5,6beta-epoxy-5alpha-cholestan-3beta-ol | Rattus norvegicus | ? | - |
? | |
3.3.2.9 | styrene epoxide + H2O | - |
Rattus norvegicus | 1-phenyl-ethane-1,2-diol | - |
? | |
3.3.2.11 | 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | - |
Rattus norvegicus | cholestane-3beta,5alpha,6beta-triol | - |
? | |
3.3.2.11 | 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O | the enzyme is equally active with both stereoisomers | Rattus norvegicus | cholestane-3beta,5alpha,6beta-triol | - |
? | |
3.3.2.11 | 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O | - |
Rattus norvegicus | cholestane-3beta,5alpha,6beta-triol | - |
? | |
3.3.2.11 | 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O | the enzyme is equally active with both stereoisomers | Rattus norvegicus | cholestane-3beta,5alpha,6beta-triol | - |
? | |
3.3.2.11 | additional information | the enzyme is distinct from the microsomal epoxide hydrolase EC 3.3.2.9 | Rattus norvegicus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.3.2.9 | styrene-epoxide hydrolase | - |
Rattus norvegicus |
3.3.2.9 | xenobiotic epoxide hydrolase | - |
Rattus norvegicus |
3.3.2.11 | cholesterol-epoxide hydrolase | - |
Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.3.2.9 | 37 | - |
assay at | Rattus norvegicus |
3.3.2.11 | 37 | - |
assay at | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.3.2.9 | 7.4 | - |
assay at | Rattus norvegicus |
3.3.2.11 | 7.4 | - |
assay at | Rattus norvegicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.3.2.9 | 0.0154 | - |
cyclohexane oxide | pH 7.4, 37°C | Rattus norvegicus | |
3.3.2.11 | 0.0037 | - |
5,6beta-epoxy-5beta-cholestan-3beta-ol | pH 7.4, 37°C, versus 5,6alpha-epoxy-5alpha-cholestan-3beta-ol | Rattus norvegicus | |
3.3.2.11 | 0.0044 | - |
5,6alpha-epoxy-5alpha-cholestan-3beta-ol | pH 7.4, 37°C, versus 5,6beta-epoxy-5alpha-cholestan-3beta-ol | Rattus norvegicus |