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Literature summary extracted from

  • Tsutsui, K.
    Tripolyphosphate is an alternative phosphodonor of the selective protein phosphorylation of liver microsomal membrane (1986), J. Biol. Chem., 261, 2645-2653.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.99.1 5'-adenylimidodiphosphate i.e. AMP-PNP, ATP analogue Rattus norvegicus
2.7.99.1 adenosine 5'-(beta,gamma-Imino)triphosphate i.e. AMP-PNP, ATP analogue Rattus norvegicus
2.7.99.1 adenosine 5'-(beta,gamma-methylene)triphosphate i.e. AMP-PCP or AMP-CPP, ATP analogue Rattus norvegicus
2.7.99.1 adenosine 5'-methylene diphosphate i.e. AMP-CP, ATP analogue Rattus norvegicus
2.7.99.1 ADP
-
 Rattus norvegicus
2.7.99.1 ATP
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.99.1 membrane
-
 Rattus norvegicus 16020
-
2.7.99.1 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.99.1 triphosphate + [microsomal membrane protein] Rattus norvegicus reversible phosphorylation in the second phase of membrane protein phosphorylation, competes with ATP-dependent phosphorylation reaction which occurs in the first phase diphosphate + phosphorylated [microsomal membrane protein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.99.1 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.99.1 from liver microsomal membranes by DEAE ion exchange chromatography and gel filtration Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.99.1 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.99.1 tetraphosphate + [microsomal membrane protein] reversible phosphorylation, substrates are 145 kD and 130 kD microsomal membrane proteins, higher activity compared to triphosphate as phosphate donor Rattus norvegicus triphosphate + phosphorylated [microsomal membrane protein]
-
 ?
2.7.99.1 triphosphate + [microsomal membrane protein] reversible phosphorylation in the second phase of membrane protein phosphorylation, competes with ATP-dependent phosphorylation reaction which occurs in the first phase Rattus norvegicus diphosphate + phosphorylated [microsomal membrane protein]
-
 ?
2.7.99.1 triphosphate + [microsomal membrane protein] reversible phosphorylation, substrates are 145 kD and 130 kD microsomal membrane proteins Rattus norvegicus diphosphate + phosphorylated [microsomal membrane protein]
-
 ?