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Literature summary extracted from

  • Turvey, E.A.; Heigenhauser, G.J.; Parolin, M.; Peters, S.J.
    Elevated n-3 fatty acids in a high-fat diet attenuate the increase in PDH kinase activity but not PDH activity in human skeletal muscle (2005), J. Appl. Physiol., 98, 350-355.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.2 additional information high-fat diet with unaltered n-3 fatty acid levels leads to increase in PDK activity and decrease in PDH activity, high-fat diet with elevated levels of n-3 fatty acids attenuates the increase in PDH kinase activity and decreases PDH activity, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.2 mitochondrion
-
 Homo sapiens 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.2 KCl
-
 Homo sapiens
2.7.11.2 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.2 ATP + pyruvate dehydrogenase Homo sapiens PDK is involved in fatty acid metabolism ADP + phosphorylated pyruvate dehydrogenase
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.2 skeletal muscle
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.11.2 additional information
-
 PDK activity in different dietary states Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.2 ATP + pyruvate dehydrogenase
-
 Homo sapiens ADP + phosphorylated pyruvate dehydrogenase
-
 ?
2.7.11.2 ATP + pyruvate dehydrogenase PDK is involved in fatty acid metabolism Homo sapiens ADP + phosphorylated pyruvate dehydrogenase
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.2 PDH kinase
-
 Homo sapiens
2.7.11.2 PDK
-
 Homo sapiens
2.7.11.2 pyruvate dehydrogenase kinase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.2 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.2 7.4
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.2 ATP
-
 Homo sapiens