EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.3.22 | 2-trans,6-trans-farnesyl diphosphate + H2O | Streptomyces coelicolor | key step in biosynthesis of geosmin | (4S,7R)-germacra-1(10)E,5E-dien-11-ol + diphosphate | - |
? | |
4.2.3.22 | 2-trans,6-trans-farnesyl diphosphate + H2O | Streptomyces coelicolor A3(2) | key step in biosynthesis of geosmin | (4S,7R)-germacra-1(10)E,5E-dien-11-ol + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.3.22 | Streptomyces coelicolor | - |
gene SC9B1.20 | - |
4.2.3.22 | Streptomyces coelicolor A3(2) | - |
gene SC9B1.20 | - |
4.2.3.75 | Streptomyces coelicolor | - |
bifunctional germacradienol/germacrene D synthase | - |
4.2.3.75 | Streptomyces coelicolor A3(2) | - |
bifunctional germacradienol/germacrene D synthase | - |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
4.2.3.22 | (2E,6E)-farnesyl diphosphate + H2O = (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate | catalytic mechanism via intermediate is (7R)-germacra-1(10),4-diene-11-ol | Streptomyces coelicolor | |
4.2.3.75 | (2E,6E)-farnesyl diphosphate = (-)-germacrene D + diphosphate | formation of (-)-germacrene D involves a stereospecific 1,3-hydride shift of H-1si of farnesyl diphosphate | Streptomyces coelicolor |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.3.22 | 2-trans,6-trans-farnesyl diphosphate + H2O | key step in biosynthesis of geosmin | Streptomyces coelicolor | (4S,7R)-germacra-1(10)E,5E-dien-11-ol + diphosphate | - |
? | |
4.2.3.22 | 2-trans,6-trans-farnesyl diphosphate + H2O | cyclization reaction, detailed mechanism, an intermediate is (7R)-germacra-1(10),4-diene-11-ol | Streptomyces coelicolor | (4S,7R)-germacra-1(10)E,5E-dien-11-ol + diphosphate | GC-MS and NMR product configuration analysis | ? | |
4.2.3.22 | 2-trans,6-trans-farnesyl diphosphate + H2O | key step in biosynthesis of geosmin | Streptomyces coelicolor A3(2) | (4S,7R)-germacra-1(10)E,5E-dien-11-ol + diphosphate | - |
? | |
4.2.3.22 | 2-trans,6-trans-farnesyl diphosphate + H2O | cyclization reaction, detailed mechanism, an intermediate is (7R)-germacra-1(10),4-diene-11-ol | Streptomyces coelicolor A3(2) | (4S,7R)-germacra-1(10)E,5E-dien-11-ol + diphosphate | GC-MS and NMR product configuration analysis | ? | |
4.2.3.22 | additional information | stereospecificity, the 1,3-hydride shift of the (-)-germacrene D synthase of Streptomyces coelicolor A3(2) is opposite to the enzyme from Solidago canadensis | Streptomyces coelicolor | ? | - |
? | |
4.2.3.22 | additional information | stereospecificity, the 1,3-hydride shift of the (-)-germacrene D synthase of Streptomyces coelicolor A3(2) is opposite to the enzyme from Solidago canadensis | Streptomyces coelicolor A3(2) | ? | - |
? | |
4.2.3.75 | (2E,6E)-farnesyl diphosphate | - |
Streptomyces coelicolor | (-)-germacrene D + diphosphate | main product is germacradienol, about 15% formation of (-)-(7S)-germacrene | ? | |
4.2.3.75 | (2E,6E)-farnesyl diphosphate | - |
Streptomyces coelicolor A3(2) | (-)-germacrene D + diphosphate | main product is germacradienol, about 15% formation of (-)-(7S)-germacrene | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.2.3.22 | germacradienol/germacrene D synthase | - |
Streptomyces coelicolor |