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Literature summary extracted from

  • Adachi, T.; Stafford, S.; Kayaba, H.; Chihara, J.; Alam, R.
    Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner (2003), J. Allergy Clin. Immunol., 111, 113-116.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.18 eotaxin activates the enzyme 4fold, induces enzyme phosphorylation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 ML-7 specific inhibitor, inhibits activation by eotaxin Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+
-
 Homo sapiens
2.7.11.18 Mg2+
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.18 150000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.18 ATP + [myosin light chain] Homo sapiens enzyme is regulating cytoskeletal rearrangement and cell motility ADP + [myosin light chain] phosphate
-
 ?
2.7.11.18 additional information Homo sapiens the enzyme mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.18 phosphoprotein eotaxin induces enzyme phosphorylation by serine/threonine protein kinases e.g. by MAP kinases ERK1/2 and p38 at Thr43, phosphorylation is required for activation of the enzyme Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.18 partially from eosinophils Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 eosinophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + H-KKRAARATSNVFA-NH2 peptide substrate Homo sapiens ADP + ?
-
 ?
2.7.11.18 ATP + [myosin light chain] enzyme is regulating cytoskeletal rearrangement and cell motility Homo sapiens ADP + [myosin light chain] phosphate
-
 ?
2.7.11.18 ATP + [myosin light chain] activated phosphorylated enzyme Homo sapiens ADP + [myosin light chain] phosphate
-
 ?
2.7.11.18 additional information the enzyme mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 MLCK
-
 Homo sapiens
2.7.11.18 myosin light chain kinase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.18 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.18 7
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Homo sapiens