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Literature summary extracted from

  • Dupuy, F.; Germot, A.; Julien, R.; Maftah, A.
    Structure/function study of Lewis alpha3- and alpha3/4-fucosyltransferases: the alpha1,4 fucosylation requires an aromatic residue in the acceptor-binding domain (2004), Glycobiology, 14, 347-356.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.65
-
 Homo sapiens
2.4.1.65
-
 Gorilla gorilla
2.4.1.65
-
 Pongo pygmaeus
2.4.1.65
-
 Hylobates lar

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.65 R110H less than 10% of the wild type alpha-1,3-activity and undetectable alpha-1,4-activity Homo sapiens
2.4.1.65 R110K less than 10% of the wild type alpha-1,3-activity and undetectable alpha-1,4-activity Homo sapiens
2.4.1.65 R110N less than 10% of the wild type alpha-1,3-activity and undetectable alpha-1,4-activity Homo sapiens
2.4.1.65 R110Q less than 10% of the wild type alpha-1,3-activity and undetectable alpha-1,4-activity Homo sapiens
2.4.1.65 R110W no alpha-1,3-activity or alpha-1,4-activity Homo sapiens
2.4.1.65 W111A alpha-1,4-activity is decreased to 10-20% of the wild type activity Homo sapiens
2.4.1.65 W111F alpha-1,4-activity is decreased to 42% of the wild type activity Homo sapiens
2.4.1.65 W111Y alpha-1,4-activity is decreased to 58% of the wild type activity Homo sapiens
2.4.1.65 W124A alpha-1,4-activity is decreased to 20% of the wild type activity Homo sapiens
2.4.1.65 W124F alpha-1,4-activity is decreased to 17% of the wild type activity Homo sapiens
2.4.1.65 W124R undetectable alpha-1,4-activity Homo sapiens
2.4.1.65 W124V undetectable alpha-1,4-activity Homo sapiens
2.4.1.65 W124Y alpha-1,4-activity is decreased to 52% of the wild type activity Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.65 0.03
-
 GDP-fucose mutant W124R, with Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin Homo sapiens
2.4.1.65 0.034
-
 GDP-fucose mutant W111Y, with Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin Homo sapiens
2.4.1.65 0.035
-
 GDP-fucose mutant W124Y, with Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin Homo sapiens
2.4.1.65 0.035
-
 GDP-fucose wildtype, with Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin Homo sapiens
2.4.1.65 0.037
-
 GDP-fucose mutant W111F, with Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin Homo sapiens
2.4.1.65 0.038
-
 GDP-fucose wildtype, with Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin Homo sapiens
2.4.1.65 0.046
-
 GDP-fucose mutant W111A, with Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin Homo sapiens
2.4.1.65 0.1
-
 Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin mutant W124R Homo sapiens
2.4.1.65 0.2
-
 Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin wildtype Homo sapiens
2.4.1.65 0.3
-
 Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin mutant W111F Homo sapiens
2.4.1.65 0.3
-
 Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin mutant W111Y Homo sapiens
2.4.1.65 1.1
-
 Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin wildtype Homo sapiens
2.4.1.65 1.3
-
 Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin mutant W124Y Homo sapiens
2.4.1.65 2.5
-
 Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin mutant W111A Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.65 41800
-
 SDS-PAGE, immunoblot Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.65 Gorilla gorilla Q8HYJ6
-
-
2.4.1.65 Gorilla gorilla Q8HYJ7
-
-
2.4.1.65 Homo sapiens P21217
-
-
2.4.1.65 Homo sapiens P51993
-
-
2.4.1.65 Homo sapiens Q11128
-
-
2.4.1.65 Hylobates lar Q8HYJ3
-
-
2.4.1.65 Pongo pygmaeus Q8HYJ4
-
-
2.4.1.65 Pongo pygmaeus Q8HYJ5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.65 GDP-fucose + Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin type 1 reaction Homo sapiens GDP + Fuc-alpha-1,2Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc-sp-biotin
-
 ?
2.4.1.65 GDP-fucose + Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin type 1 reaction Pongo pygmaeus GDP + Fuc-alpha-1,2Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc-sp-biotin
-
 ?
2.4.1.65 GDP-fucose + Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin type 1 reaction Hylobates lar GDP + Fuc-alpha-1,2Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc-sp-biotin
-
 ?
2.4.1.65 GDP-fucose + Fuc-alpha-1,2Gal-beta-1,3GlcNAc-sp-biotin type 1 reaction Gorilla gorilla GDP + Fuc-alpha-1,2Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc-sp-biotin
-
 ?
2.4.1.65 GDP-fucose + Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin type 2 reaction Homo sapiens GDP + Fuc-alpha-1,2Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc-sp-biotin
-
 ?
2.4.1.65 GDP-fucose + Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin type 2 reaction Gorilla gorilla GDP + Fuc-alpha-1,2Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc-sp-biotin
-
 ?
2.4.1.65 GDP-fucose + Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin type 2 reaction Pongo pygmaeus GDP + Fuc-alpha-1,2Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc-sp-biotin
-
 ?
2.4.1.65 GDP-fucose + Fuc-alpha-1,2Gal-beta-1,4GlcNAc-sp-biotin type 2 reaction Hylobates lar GDP + Fuc-alpha-1,2Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc-sp-biotin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.65 alpha-3-FUT
-
 Homo sapiens
2.4.1.65 alpha-3-FUT
-
 Gorilla gorilla
2.4.1.65 alpha-3/4-FUT
-
 Homo sapiens
2.4.1.65 alpha-3/4-FUT
-
 Pongo pygmaeus
2.4.1.65 alpha-3/4-FUT
-
 Hylobates lar
2.4.1.65 alpha-3/4-FUT
-
 Gorilla gorilla
2.4.1.65 fucosyltransferase 3
-
 Homo sapiens
2.4.1.65 fucosyltransferase 3
-
 Pongo pygmaeus
2.4.1.65 fucosyltransferase 5
-
 Homo sapiens
2.4.1.65 fucosyltransferase 5
-
 Pongo pygmaeus
2.4.1.65 fucosyltransferase 5
-
 Hylobates lar
2.4.1.65 fucosyltransferase 5
-
 Gorilla gorilla
2.4.1.65 fucosyltransferase 6
-
 Homo sapiens
2.4.1.65 fucosyltransferase 6
-
 Gorilla gorilla
2.4.1.65 FucT-III
-
 Homo sapiens
2.4.1.65 FucT-III
-
 Pongo pygmaeus
2.4.1.65 FucT-V
-
 Homo sapiens
2.4.1.65 FucT-V
-
 Pongo pygmaeus
2.4.1.65 FucT-V
-
 Hylobates lar
2.4.1.65 FucT-V
-
 Gorilla gorilla
2.4.1.65 FucT-VI
-
 Homo sapiens
2.4.1.65 FucT-VI
-
 Gorilla gorilla
2.4.1.65 FUT3
-
 Homo sapiens
2.4.1.65 FUT3
-
 Pongo pygmaeus
2.4.1.65 FUT5
-
 Homo sapiens
2.4.1.65 FUT5
-
 Pongo pygmaeus
2.4.1.65 FUT5
-
 Hylobates lar
2.4.1.65 FUT5
-
 Gorilla gorilla
2.4.1.65 FUT6
-
 Homo sapiens
2.4.1.65 FUT6
-
 Gorilla gorilla
2.4.1.65 Lewis alpha-3-fucosyltransferase
-
 Homo sapiens
2.4.1.65 Lewis alpha-3-fucosyltransferase
-
 Gorilla gorilla
2.4.1.65 Lewis alpha-3/4-fucosyltransferase
-
 Homo sapiens
2.4.1.65 Lewis alpha-3/4-fucosyltransferase
-
 Pongo pygmaeus
2.4.1.65 Lewis alpha-3/4-fucosyltransferase
-
 Hylobates lar
2.4.1.65 Lewis alpha-3/4-fucosyltransferase
-
 Gorilla gorilla