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Literature summary extracted from

  • Ahel, D.; Slade, D.; Mocibob, M.; Soll, D.; Weygand-Durasevic, I.
    Selective inhibition of divergent seryl-tRNA synthetases by serine analogues (2005), FEBS Lett., 579, 4344-4348.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.1.1.11 expression in Escherichia coli Methanosarcina barkeri

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.11 serinamide inhibition of methanogenic type seryl-tRNA synthetase, no inhibition of bacterial type seryl-tRNA synthetase Methanosarcina barkeri
6.1.1.11 serine hydroxamate
-
 Methanosarcina barkeri
6.1.1.11 serine methyl ester
-
 Methanosarcina barkeri

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.11 Methanosarcina barkeri
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.11 ATP + L-serine + tRNASer
-
 Methanosarcina barkeri AMP + diphosphate + L-seryl-tRNASer
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.11 bacterial type seryl-tRNA synthetase
-
 Methanosarcina barkeri
6.1.1.11 methanogenic type seryl-tRNA synthetase
-
 Methanosarcina barkeri
6.1.1.11 SerRS
-
 Methanosarcina barkeri

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.1.1.11 0.0032
-
 serinamide methanogenic type seryl-tRNA synthetase Methanosarcina barkeri
6.1.1.11 0.18
-
 serine hydroxamate methanogenic type seryl-tRNA synthetase Methanosarcina barkeri
6.1.1.11 0.55
-
 serine methyl ester methanogenic type seryl-tRNA synthetase Methanosarcina barkeri
6.1.1.11 1
-
 serinamide bacterial type seryl-tRNA synthetase Methanosarcina barkeri
6.1.1.11 1.6
-
 serine hydroxamate bacterial type seryl-tRNA synthetase Methanosarcina barkeri
6.1.1.11 3.5
-
 serine methyl ester bacterial type seryl-tRNA synthetase Methanosarcina barkeri