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Literature summary extracted from

  • Leboulle, G.; Muller, U.
    Synergistic activation of insect cAMP-dependent protein kinase A (type II) by cyclicAMP and cyclicGMP (2004), FEBS Lett., 576, 216-220.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP dependent on, acts synergistically with cGMP, binding site domain structure on the regulatory subunit RII Apis mellifera
2.7.11.11 cGMP activates, acts synergistically with cAMP Apis mellifera
2.7.11.11 additional information phosphate-binding cassettes PCB of domain A and B of the regulatory subunits Apis mellifera

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.11 regulatory subunit RII, DNA sequence determination and analysis, phylogenetic analysis Apis mellifera

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
Apis mellifera

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Apis mellifera Q6ZXJ1
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.11 PKAII holoenzyme from bee brain by ion exchange, adsorption, and cAMP-affinity chromatography, thereby dissociation of regulatory and catalytic subunits, and reconstitution Apis mellifera

Renatured (Commentary)

EC Number Renatured (Comment) Organism
2.7.11.11 reconstitution of holoenzyme from purified subunits in 50 mM Tris-HCl, pH 7.8, 1 mM EDTA, 1 mM EGTA, 10 mM 2-mercaptoethanol, and 0.1 M NaCl Apis mellifera

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.11 brain
-
Apis mellifera
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + phosphatase inhibitor PKI
-
Apis mellifera ADP + phosphorylated phosphatase inhibitor PKI
-
?

Subunits

EC Number Subunits Comment Organism
2.7.11.11 More structure, deduced from DNA and amino acid sequence, analysis and comparison Apis mellifera

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKAII
-
Apis mellifera
2.7.11.11 protein kinase A type II
-
Apis mellifera

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.11.11 20
-
assay at Apis mellifera

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.11.11 7.5
-
assay at Apis mellifera

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
Apis mellifera