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Literature summary extracted from

  • Yasuda, S.; Kumar, A.P.; Liu, M.Y.; Sakakibara, Y.; Suiko, M.; Chen, L.; Liu, M.C.
    Identification of a novel thyroid hormone-sulfating cytosolic sulfotransferase, SULT1 ST5, from zebrafish (2005), FEBS J., 272, 3828-3837.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.8.2.1 recombinant enzyme form SULT1 ST5 is expressed using the pGEX-2TK bacterial expression system, expression in BL21 (DE3) cells Danio rerio

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 Cd2+ recombinant enzyme form SULT1 ST5 Danio rerio
2.8.2.1 Co2+ recombinant enzyme form SULT1 ST5 Danio rerio
2.8.2.1 Cu2+ recombinant enzyme form SULT1 ST5 Danio rerio
2.8.2.1 Fe2+ recombinant enzyme form SULT1 ST5 Danio rerio
2.8.2.1 Hg2+ recombinant enzyme form SULT1 ST5 Danio rerio
2.8.2.1 Pb2+ recombinant enzyme form SULT1 ST5 Danio rerio
2.8.2.1 Zn2+ recombinant enzyme form SULT1 ST5 Danio rerio

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.1 0.0277
-
3,3',5-triiodo-D-thyronine pH 8.0, 28°C, enzyme form SULT1 ST5 Danio rerio
2.8.2.1 0.0387
-
3,3',5-triiodo-L-thyronine pH 8.0, 28°C, enzyme form SULT1 ST5 Danio rerio
2.8.2.1 0.0445
-
L-thyroxine pH 8.0, 28°C, enzyme form SULT1 ST5 Danio rerio
2.8.2.1 0.0977
-
beta-naphthol pH 8.0, 28°C, enzyme form SULT1 ST5 Danio rerio

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.1 cytosol
-
Danio rerio 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.8.2.1 Mn2+ significant stimulation of enzyme form SULT1 ST5 Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Danio rerio
-
recombinant enzyme form SULT1 ST5
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.2.1 recombinant enzyme form SULT1 ST5 expressed in BL21 (DE3) cells Danio rerio

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 embryo significant level of expression at the beginning of the hatching period during embryogenesis, enzyme form SULT1 ST5 Danio rerio
-
2.8.2.1 larva gradual increase in expression to a high level of expression throughout the larval stage of maturity, enzyme form SULT1 ST5 Danio rerio
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylylsulfate + 2-naphthol recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + 2-naphthylsulfate
-
?
2.8.2.1 3'-phosphoadenylylsulfate + 3,3',5-triiodo-D-thyronine recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + 3,3',5-triiodo-D-thyronine 4'-sulfate
-
?
2.8.2.1 3'-phosphoadenylylsulfate + 3,3',5-triiodo-L-thyronine recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + 3,3',5-triiodo-L-thyronine 4'-sulfate
-
?
2.8.2.1 3'-phosphoadenylylsulfate + 4-nitrophenol recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + 4-nitrophenyl sulfate
-
?
2.8.2.1 3'-phosphoadenylylsulfate + butylated hydroxyanisole recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylylsulfate + caffeic acid recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylylsulfate + catechin recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylylsulfate + chlorogenic acid recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylylsulfate + daidzein recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylylsulfate + gallic acid recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylylsulfate + genistein recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylylsulfate + kaempferol recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylylsulfate + L-thyroxine recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + L-thyroxine 4'-sulfate
-
?
2.8.2.1 3'-phosphoadenylylsulfate + myricetin recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylylsulfate + n-propyl gallate recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + ?
-
?
2.8.2.1 3'-phosphoadenylylsulfate + quercetin recombinant enzyme form SULT1 ST5 Danio rerio adenosine 3',5'-bisphosphate + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT1 ST5
-
Danio rerio

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.1 6
-
with beta-naphthol as substrate, two optima at pH 6.0 and at pH 9.0 with 3,3',5-triiodo-L-thyronine as substrate, enzyme form SULT1 ST5 Danio rerio
2.8.2.1 9
-
two optima at pH 6.0 and at pH 9.0 with 3,3',5-triiodo-L-thyronine as substrate, enzyme form SULT1 ST5 Danio rerio