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Literature summary extracted from

  • Mergler, S.; Dannowski, H.; Bednarz, J.; Engelmann, K.; Hartmann, C.; Pleyer, U.
    Calcium influx induced by activation of receptor tyrosine kinases in SV40-transfected human corneal endothelial cells (2003), Exp. Eye Res., 77, 485-495.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 genistein
-
 Homo sapiens
2.7.10.1 lavendustin A
-
 Homo sapiens
2.7.10.1 additional information enzyme inhibition leads to a reduction of capacitative calcium entry CCE in SV-40 transfected endothelial cells Homo sapiens
2.7.10.1 tyrphostin 51
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.10.1 Ca2+ L-type Ca2+ channel activity is induced by enzyme activity regulating the Ca2+ flux and intracellular Ca2+ concentration, capacitative Ca2+ entry measurements using a fluorescent method Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.1 additional information Homo sapiens the enzyme is responsible for induction of calcium influx in corneal endothelial cells, FGF receptor tyrosine kinase activity is linked to L-type Ca2+ channel activity, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Homo sapiens
-
 2 enzyme forms FGFR1 and FGFR2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.1 corneal epithelium immortalized SV40-transfected corneal endothelial cells Homo sapiens
-
2.7.10.1 endothelial cell immortalized SV40-transfected corneal endothelial cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.1 additional information the enzyme is responsible for induction of calcium influx in corneal endothelial cells, FGF receptor tyrosine kinase activity is linked to L-type Ca2+ channel activity, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 FGF receptor tyrosine kinase
-
 Homo sapiens
2.7.10.1 FGFR
-
 Homo sapiens
2.7.10.1 fibroblast growth factor receptor
-
 Homo sapiens
2.7.10.1 receptor tyrosine kinase
-
 Homo sapiens
2.7.10.1 RTK
-
 Homo sapiens