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Literature summary extracted from

  • Oude Weernink, P.A.; Schmidt, M.; Jakobs, K.H.
    Regulation and cellular roles of phosphoinositide 5-kinases (2004), Eur. J. Pharmacol., 500, 87-99.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.68 lysophosphatidic acid
-
 Saccharomyces cerevisiae
2.7.1.68 lysophosphatidic acid
-
 Schizosaccharomyces pombe
2.7.1.68 lysophosphatidic acid
-
 Candida albicans
2.7.1.68 lysophosphatidic acid mechanism overview Mus musculus
2.7.1.68 lysophosphatidic acid mechanism overview Homo sapiens
2.7.1.68 small GTPase Arf
-
 Saccharomyces cerevisiae
2.7.1.68 small GTPase Arf
-
 Schizosaccharomyces pombe
2.7.1.68 small GTPase Arf
-
 Candida albicans
2.7.1.68 small GTPase Arf involved in membrane receptor-mediated regulation, acts via effectors, mechanism overview Mus musculus
2.7.1.68 small GTPase Arf involved in membrane receptor-mediated regulation, acts via effectors, mechanism overview Homo sapiens
2.7.1.68 small GTPase Rho
-
 Saccharomyces cerevisiae
2.7.1.68 small GTPase Rho
-
 Schizosaccharomyces pombe
2.7.1.68 small GTPase Rho
-
 Candida albicans
2.7.1.68 small GTPase Rho involved in membrane receptor-mediated regulation, acts via effectors, mechanism overview Mus musculus
2.7.1.68 small GTPase Rho involved in membrane receptor-mediated regulation, acts via effectors, mechanism overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.68 membrane associated Saccharomyces cerevisiae 16020
-
2.7.1.68 membrane associated Candida albicans 16020
-
2.7.1.68 additional information subcellular localization of isozymes is regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, overview Candida albicans
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.68 Mg2+
-
 Mus musculus
2.7.1.68 Mg2+
-
 Homo sapiens
2.7.1.68 Mg2+
-
 Saccharomyces cerevisiae
2.7.1.68 Mg2+
-
 Schizosaccharomyces pombe
2.7.1.68 Mg2+
-
 Candida albicans

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.68 68000
-
 x * 68000, isozymes alpha or beta, x * 90000, isozyme gamma Mus musculus
2.7.1.68 68000
-
 x * 68000, isozymes alpha or beta, x * 90000, isozyme gamma Homo sapiens
2.7.1.68 90000
-
 x * 68000, isozymes alpha or beta, x * 90000, isozyme gamma Mus musculus
2.7.1.68 90000
-
 x * 68000, isozymes alpha or beta, x * 90000, isozyme gamma Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Mus musculus 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Homo sapiens 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Saccharomyces cerevisiae 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Schizosaccharomyces pombe 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate Candida albicans 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, in gene expression and cell survival, and in establishment of cell morphology and during temperature-induced hyphal growth, respectively, overview ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 additional information Candida albicans activities of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview ?
-
 ?
2.7.1.68 additional information Mus musculus subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview ?
-
 ?
2.7.1.68 additional information Homo sapiens subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview ?
-
 ?
2.7.1.68 additional information Saccharomyces cerevisiae subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview ?
-
 ?
2.7.1.68 additional information Schizosaccharomyces pombe subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.68 Candida albicans
-
-
-
2.7.1.68 Homo sapiens
-
 enzyme form type I, 3 isozymes alpha, beta, gamma in several splicing variants
-
2.7.1.68 Mus musculus
-
 enzyme form type I, 3 isozymes alpha, beta, gamma in several splicing variants
-
2.7.1.68 Saccharomyces cerevisiae
-
-
-
2.7.1.68 Schizosaccharomyces pombe
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.1.68 phosphoprotein the enzyme is negatively regulated by, besides other mechanisms, phosphorylation by casein kinase I Schizosaccharomyces pombe
2.7.1.68 phosphoprotein the enzyme is negatively regulated by, besides other mechanisms, phosphorylation, autophosphorylation is enhanced by phosphatidylinositol Saccharomyces cerevisiae
2.7.1.68 phosphoprotein the enzyme is negatively regulated by, besides other mechanisms, phosphorylation, autophosphorylation is enhanced by phosphatidylinositol Candida albicans
2.7.1.68 phosphoprotein the enzyme is negatively regulated by, besides other mechanisms, phosphorylation, autophosphorylation is enhanced by phosphatidylinositol, Ca2+ induces dephosphorylation of isozyme gamma at serine 264, phosphorylation by 9,11-dideoxy-9alpha,11alpha-methanoepoxyprostaglandin U46619 is inhibited by genistein in platelets, tyrosine phosphorylation by focal adhesion kinase of isozyme gamma brain splice variant associated to the FERM domain of talin in brain Homo sapiens
2.7.1.68 phosphoprotein the enzyme is negatively regulated by, besides other mechanisms, phosphorylation, autophosphorylation is enhanced by phosphatidylinositol, isozyme alpha is phosphorylated by cAMP-dependent protein kinase at serine 214, Ca2+ induces dephosphorylation of isozyme gamma at serine 264, phosphorylation by 9,11-dideoxy-9alpha,11alpha-methanoepoxyprostaglandin U46619 is inhibited by genistein in platelets, tyrosine phosphorylation by focal adhesion kinase of isozyme gamma brain splice variant associated to the FERM domain of talin in brain Mus musculus

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate an activation loop spanning the catalytic domain is responsible for determination of both substrate specificity and subcellular targeting Mus musculus
a
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate an activation loop spanning the catalytic domain is responsible for determination of both substrate specificity and subcellular targeting Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.68 blood platelet
-
 Mus musculus
-
2.7.1.68 blood platelet
-
 Homo sapiens
-
2.7.1.68 brain
-
 Mus musculus
-
2.7.1.68 brain
-
 Homo sapiens
-
2.7.1.68 erythrocyte
-
 Mus musculus
-
2.7.1.68 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Saccharomyces cerevisiae ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Schizosaccharomyces pombe ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 Candida albicans ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview Saccharomyces cerevisiae ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, and in gene expression and cell survival, overview Schizosaccharomyces pombe ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is an important membrane lipid in several cellular processes e.g. in actin cytoskeleton regulation and membrane trafficking, in signaling of membrane receptors, for ion channel activity, in gene expression and cell survival, and in establishment of cell morphology and during temperature-induced hyphal growth, respectively, overview Candida albicans ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
-
 ?
2.7.1.68 additional information activities of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview Candida albicans ?
-
 ?
2.7.1.68 additional information subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview Mus musculus ?
-
 ?
2.7.1.68 additional information subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview Homo sapiens ?
-
 ?
2.7.1.68 additional information subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview Saccharomyces cerevisiae ?
-
 ?
2.7.1.68 additional information subcellular localization and activity of isozymes are regulated by membrane receptors, by phosphorylation, and by small GTPases of the Rho and Arf families, detailed phosphoinositide metabolism, overview Schizosaccharomyces pombe ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.68 ? x * 68000, isozymes alpha or beta, x * 90000, isozyme gamma Mus musculus
2.7.1.68 ? x * 68000, isozymes alpha or beta, x * 90000, isozyme gamma Homo sapiens
2.7.1.68 More 2 dimerization domains may be involved in subcellular targeting in isozyme beta Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.7.1.68 MSS4p
-
 Saccharomyces cerevisiae
2.7.1.68 MSS4p
-
 Candida albicans
2.7.1.68 phosphatidylinositol 4-phosphate 5-kinase
-
 Mus musculus
2.7.1.68 phosphatidylinositol 4-phosphate 5-kinase
-
 Homo sapiens
2.7.1.68 phosphatidylinositol 4-phosphate 5-kinase
-
 Saccharomyces cerevisiae
2.7.1.68 phosphatidylinositol 4-phosphate 5-kinase
-
 Schizosaccharomyces pombe
2.7.1.68 phosphatidylinositol 4-phosphate 5-kinase
-
 Candida albicans
2.7.1.68 PIP5K type I
-
 Mus musculus
2.7.1.68 PIP5K type I
-
 Homo sapiens
2.7.1.68 PIP5K type I
-
 Saccharomyces cerevisiae
2.7.1.68 PIP5K type I
-
 Schizosaccharomyces pombe
2.7.1.68 PIP5K type I
-
 Candida albicans
2.7.1.68 PIP5KI
-
 Mus musculus
2.7.1.68 PIP5KI
-
 Homo sapiens
2.7.1.68 PIP5KI
-
 Saccharomyces cerevisiae
2.7.1.68 PIP5KI
-
 Schizosaccharomyces pombe
2.7.1.68 PIP5KI
-
 Candida albicans

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.68 ATP
-
 Mus musculus
2.7.1.68 ATP
-
 Homo sapiens
2.7.1.68 ATP
-
 Saccharomyces cerevisiae
2.7.1.68 ATP
-
 Schizosaccharomyces pombe
2.7.1.68 ATP
-
 Candida albicans