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Literature summary extracted from

  • Min, J.; Traynor, D.; Stegner, A.L.; Zhang, L.; Hanigan, M.H.; Alexander, H.; Alexander, S.
    Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin (2005), Eukaryot. Cell, 4, 178-189.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.91 overexpression of gene sgkA leads to increased resistance to the anticancer drug cisplatin and altered growth behaviour Dictyostelium discoideum

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.91 additional information disruption mutants of genes sgkA and sgkB, single mutants with reduced activity, or double mutants nearly inactive, show increased sensitivity to the anticancer drug cisplatin and altered growth behaviour Dictyostelium discoideum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.91 cytosol
-
 Dictyostelium discoideum 5829
-
2.7.1.91 nucleus
-
 Dictyostelium discoideum 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.91 Mg2+
-
 Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.91 ATP + sphingosine Dictyostelium discoideum
-
 ADP + sphingosine 1-phosphate
-
 ?
2.7.1.91 additional information Dictyostelium discoideum sphingosine 1-phosphate is responsible for resistance to the anticancer drug cisplatin ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Dictyostelium discoideum
-
 isozymes SgkA and SgkB encoded by the genes sgkA and sgkB
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 pseudopodium
-
 Dictyostelium discoideum
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.91 additional information
-
 activity of mutant strains Dictyostelium discoideum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.91 ATP + sphingosine
-
 Dictyostelium discoideum ADP + sphingosine 1-phosphate
-
 ?
2.7.1.91 additional information sphingosine 1-phosphate is responsible for resistance to the anticancer drug cisplatin Dictyostelium discoideum ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.91 SGK
-
 Dictyostelium discoideum
2.7.1.91 sphinganine kinase
-
 Dictyostelium discoideum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.91 28
-
 assay at Dictyostelium discoideum

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.91 ATP
-
 Dictyostelium discoideum