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Literature summary extracted from

  • Beverley, S.M.; Owens, K.L.; Showalter, M.; Griffith, C.L.; Doering, T.L.; Jones, V.C.; McNeil, M.R.
    Eukaryotic UDP-galactopyranose mutase (GLF gene) in microbial and metazoal pathogens (2005), Eukaryot. Cell, 4, 1147-1154.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
5.4.99.9 drug development UGM inhibition may provide an attractive drug target in those eukaryotes where galactofuranose plays a critical role in cellular viability and virulence Caenorhabditis elegans
5.4.99.9 drug development UGM inhibition may provide an attractive drug target in those eukaryotes where galactofuranose plays a critical role in cellular viability and virulence Cryptococcus neoformans
5.4.99.9 drug development UGM inhibition may provide an attractive drug target in those eukaryotes where galactofuranose plays a critical role in cellular viability and virulence Leishmania major
5.4.99.9 drug development UGM inhibition may provide an attractive drug target in those eukaryotes where galactofuranose plays a critical role in cellular viability and virulence Trypanosoma cruzi

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.99.9 expression in Escherichia coli Caenorhabditis elegans
5.4.99.9 expression in Escherichia coli Cryptococcus neoformans
5.4.99.9 expression in Escherichia coli Leishmania major
5.4.99.9 expression in Escherichia coli Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.99.9 UDP-galactopyranose Caenorhabditis elegans
-
UDP-galactofuranose
-
r
5.4.99.9 UDP-galactopyranose Cryptococcus neoformans
-
UDP-galactofuranose
-
r
5.4.99.9 UDP-galactopyranose Leishmania major
-
UDP-galactofuranose
-
r
5.4.99.9 UDP-galactopyranose Trypanosoma cruzi
-
UDP-galactofuranose
-
r

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.9 Caenorhabditis elegans
-
-
-
5.4.99.9 Cryptococcus neoformans Q5KEL8
-
-
5.4.99.9 Leishmania major Q5EEK0
-
-
5.4.99.9 Trypanosoma cruzi Q5EEK1
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.9 UDP-galactopyranose
-
Caenorhabditis elegans UDP-galactofuranose
-
r
5.4.99.9 UDP-galactopyranose
-
Cryptococcus neoformans UDP-galactofuranose
-
r
5.4.99.9 UDP-galactopyranose
-
Leishmania major UDP-galactofuranose
-
r
5.4.99.9 UDP-galactopyranose
-
Trypanosoma cruzi UDP-galactofuranose
-
r
5.4.99.9 UDP-galactopyranose pH 7.1, 30°C Caenorhabditis elegans UDP-galactofuranose
-
r
5.4.99.9 UDP-galactopyranose pH 7.1, 30°C Cryptococcus neoformans UDP-galactofuranose
-
r
5.4.99.9 UDP-galactopyranose pH 7.1, 30°C Leishmania major UDP-galactofuranose
-
r
5.4.99.9 UDP-galactopyranose pH 7.1, 30°C Trypanosoma cruzi UDP-galactofuranose
-
r

Synonyms

EC Number Synonyms Comment Organism
5.4.99.9 GLF gene product
-
Caenorhabditis elegans
5.4.99.9 GLF gene product
-
Cryptococcus neoformans
5.4.99.9 GLF gene product
-
Leishmania major
5.4.99.9 GLF gene product
-
Trypanosoma cruzi
5.4.99.9 UDP-galactopyranose mutase
-
Caenorhabditis elegans
5.4.99.9 UDP-galactopyranose mutase
-
Cryptococcus neoformans
5.4.99.9 UDP-galactopyranose mutase
-
Leishmania major
5.4.99.9 UDP-galactopyranose mutase
-
Trypanosoma cruzi
5.4.99.9 UGM
-
Caenorhabditis elegans
5.4.99.9 UGM
-
Cryptococcus neoformans
5.4.99.9 UGM
-
Leishmania major
5.4.99.9 UGM
-
Trypanosoma cruzi

Cofactor

EC Number Cofactor Comment Organism Structure
5.4.99.9 FAD
-
Caenorhabditis elegans
5.4.99.9 FAD
-
Cryptococcus neoformans
5.4.99.9 FAD
-
Leishmania major
5.4.99.9 FAD
-
Trypanosoma cruzi