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Literature summary extracted from

  • Nakano, H.; Ogura, K.; Takahashi, E.; Harada, T.; Nishiyama, T.; Muro, K.; Hiratsuka, A.; Kadota, S.; Watabe, T.
    Regioselective monosulfation and disulfation of the phytoestrogens daidzein and genistein by human liver sulfotransferases (2004), Drug Metab. Pharmacokinet., 19, 216-226.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.8.2.1 0.00047
-
 daidzein enzyme form SULT1A1, 7-sulfate formation Homo sapiens
2.8.2.1 0.00051
-
 genistein enzyme form SULT1A1, 7-sulfate formation Homo sapiens
2.8.2.1 0.00052
-
 genistein enzyme form SULT1A1, 4'-sulfate formation Homo sapiens
2.8.2.1 0.00054
-
 daidzein enzyme form SULT1A1, 4'-sulfate formation Homo sapiens
2.8.2.1 0.00257
-
 daidzein enzyme form SULT1E1, 7-sulfate formation Homo sapiens
2.8.2.1 0.00279
-
 genistein enzyme form SULT1E1, 7-sulfate formation Homo sapiens
2.8.2.1 0.00294
-
 genistein enzyme form SULT1E1, 4'-sulfate formation Homo sapiens
2.8.2.1 0.00324
-
 daidzein enzyme form SULT1E1, 4'-sulfate formation Homo sapiens
2.8.2.1 0.0114
-
 genistein 4'-sulfate enzyme form SULT1A1 Homo sapiens
2.8.2.1 0.025
-
 genistein enzyme form SULT2A1, 7-sulfate formation Homo sapiens
2.8.2.1 0.0266
-
 genistein 4'-sulfate enzyme form SULT1E1 Homo sapiens
2.8.2.1 0.03
-
 genistein 7-sulfate enzyme form SULT1E1 Homo sapiens
2.8.2.1 0.0316
-
 genistein 7-sulfate enzyme form SULT1A1 Homo sapiens
2.8.2.1 0.0435
-
 daidzein 7-sulfate enzyme form SULT1E1 Homo sapiens
2.8.2.1 0.0443
-
 daidzein 4'-sulfate enzyme form SULT1A1 Homo sapiens
2.8.2.1 0.0456
-
 daidzein enzyme form SULT2A1, 7-sulfate formation Homo sapiens
2.8.2.1 0.0511
-
 daidzein enzyme form SULT2A1, 4'-sulfate formation Homo sapiens
2.8.2.1 0.0516
-
 daidzein 4'-sulfate enzyme form SULT1E1 Homo sapiens
2.8.2.1 0.0559
-
 genistein enzyme form SULT2A1, 4'-sulfate formation Homo sapiens
2.8.2.1 0.0699
-
 daidzein 7-sulfate enzyme form SULT1A1 Homo sapiens
2.8.2.1 0.371
-
 genistein enzyme form SULT1A3, 4'-sulfate formation Homo sapiens
2.8.2.1 0.407
-
 daidzein enzyme form SULT1A3, 4'-sulfate formation Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.1 cytosol enzyme form SULT1A1 Homo sapiens 5829
-
2.8.2.1 cytosol enzyme form SULT1A3 Homo sapiens 5829
-
2.8.2.1 cytosol enzyme form SULT1E1 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 additional information Homo sapiens SULT1A1, occurring in liver plays the most important role among the human sulfotransferases in the hepatic cytosolic 7-preferential sulfation of phytoestrogens ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens
-
 enzyme form SULT1A1, recombinant
-
2.8.2.1 Homo sapiens
-
 enzyme form SULT1A3, recombinant
-
2.8.2.1 Homo sapiens
-
 enzyme form SULT1E1, recombinant
-
2.8.2.1 Homo sapiens
-
 enzyme form SULT2A1, recombinant
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 liver enzyme form SULT1A1 Homo sapiens
-
2.8.2.1 liver enzyme form SULT1A3 Homo sapiens
-
2.8.2.1 liver enzyme form SULT1E1 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 3'-phosphoadenylylsulfate + daidzein enzyme form SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 4'-sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + daidzein enzyme form SULT1A1, ratio of 7-sulfate formation to 4'-sulfate formation is 4.4 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 7-sulfate + daidzein 4'-sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + daidzein enzyme form SULT1E1, ratio of 7-sulfate formation to 4'-sulfate formation is 1.1 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 7-sulfate + daidzein 4'-sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + daidzein enzyme form SULT2A1, ratio of 7-sulfate formation to 4'-sulfate formation is 11.8 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 7-sulfate + daidzein 4'-sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + daidzein 4'-sulfate enzyme form SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 4',7-disulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + daidzein 4'-sulfate enzyme form SULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 4',7-disulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + daidzein 7-sulfate enzyme form SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 4',7-disulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + daidzein 7-sulfate enzyme form SULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + daidzein 4',7-disulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + genistein enzyme form SULT1A1, ratio of 7-sulfate formation to 4'-sulfate formation is 8.8 Homo sapiens adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + genistein enzyme form SULT1E1, ratio of 7-sulfate formation to 4'-sulfate formation is 1.1 Homo sapiens adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + genistein enzyme form SULT2A1, ratio of 7-sulfate formation to 4'-sulfate formation is 8.8 Homo sapiens adenosine 3',5'-bisphosphate + genistein 7-sulfate + genistein 4'-sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + genistein enzyme form SULT1A3 Homo sapiens adenosine 3',5'-bisphosphate + genistein 4'-sulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + genistein 4'-sulfate enzyme form SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + genistein 4',7-disulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + genistein 4'-sulfate enzyme form SULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + genistein 4',7-disulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + genistein 7-sulfate enzyme form SULT1A1 Homo sapiens adenosine 3',5'-bisphosphate + genistein 4',7-disulfate
-
 ?
2.8.2.1 3'-phosphoadenylylsulfate + genistein 7-sulfate enzyme form SULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + genistein 4',7-disulfate
-
 ?
2.8.2.1 additional information SULT1A1, occurring in liver plays the most important role among the human sulfotransferases in the hepatic cytosolic 7-preferential sulfation of phytoestrogens Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 SULT1A1
-
 Homo sapiens
2.8.2.1 SULT1A3
-
 Homo sapiens
2.8.2.1 SULT1E1
-
 Homo sapiens
2.8.2.1 SULT2A1
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.8.2.1 0.00016
-
 daidzein 7-sulfate enzyme form SULT1A1 Homo sapiens
2.8.2.1 0.00033
-
 daidzein enzyme form SULT2A1, 4'-sulfate formation Homo sapiens
2.8.2.1 0.00116
-
 genistein 7-sulfate enzyme form SULT1A1 Homo sapiens
2.8.2.1 0.0015
-
 genistein enzyme form SULT2A1, 4'-sulfate formation Homo sapiens
2.8.2.1 0.00183
-
 daidzein 4'-sulfate enzyme form SULT1A1 Homo sapiens
2.8.2.1 0.0035
-
 daidzein enzyme form SULT2A1, 7-sulfate formation Homo sapiens
2.8.2.1 0.005
-
 daidzein enzyme form SULT1A3, 4'-sulfate formation Homo sapiens
2.8.2.1 0.0055
-
 daidzein enzyme form SULT1A1, 4'-sulfate formation Homo sapiens
2.8.2.1 0.0062
-
 genistein enzyme form SULT2A1, 7-sulfate formation Homo sapiens
2.8.2.1 0.0067
-
 genistein 4'-sulfate enzyme form SULT1A1 Homo sapiens
2.8.2.1 0.013
-
 genistein enzyme form SULT1A1, 4'-sulfate formation Homo sapiens
2.8.2.1 0.02
-
 daidzein enzyme form SULT1A1, 7-sulfate formation Homo sapiens
2.8.2.1 0.024
-
 genistein enzyme form SULT1A3, 4'-sulfate formation Homo sapiens
2.8.2.1 0.035
-
 genistein 4'-sulfate enzyme form SULT1E1 Homo sapiens
2.8.2.1 0.06
-
 genistein 7-sulfate enzyme form SULT1E1 Homo sapiens
2.8.2.1 0.063
-
 daidzein 4'-sulfate enzyme form SULT1E1 Homo sapiens
2.8.2.1 0.076
-
 daidzein 7-sulfate enzyme form SULT1E1 Homo sapiens
2.8.2.1 0.095
-
 daidzein enzyme form SULT1E1, 7-sulfate formation Homo sapiens
2.8.2.1 0.1065
-
 daidzein enzyme form SULT1E1, 4'-sulfate formation Homo sapiens
2.8.2.1 0.11
-
 genistein enzyme form SULT1A1, 7-sulfate formation Homo sapiens
2.8.2.1 0.12
-
 genistein enzyme form SULT1E1, 7-sulfate formation Homo sapiens
2.8.2.1 0.124
-
 genistein enzyme form SULT1E1, 4'-sulfate formation Homo sapiens