Literature summary extracted from

Sasamura, T.; Sasaki, N.; Miyashita, F.; Nakao, S.; Ishikawa, H.O.; Ito, M.; Kitagawa, M.; Harigaya, K.; Spana, E.; Bilder, D.; Perrimon, N.; Matsuno, K.
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions (2003), Development, 130, 4785-4795.

Protein Variants

EC Number	Protein Variants	Comment	Organism
2.4.1.221	additional information	enzyme disruption mutant, enzyme is essential for Notch signaling, Fringe function, for physical interaction of Notch with its ligand Delta, and lateral inhibition during neuroblast segregation	Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.4.1.221	additional information	Drosophila melanogaster	essential for Notch signaling	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.4.1.221	Drosophila melanogaster	Q9V6X7	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.4.1.221	additional information	essential for Notch signaling	Drosophila melanogaster	?	-	?

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Release 2023.1 (January 2023)