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Literature summary extracted from

  • Zhao, X.; Miller, J.R.; Jiang, Y.; Marletta, M.A.; Cronan, J.E.
    Assembly of the covalent linkage between lipoic acid and its cognate enzymes (2003), Chem. Biol., 10, 1293-1302.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
6.3.1.20 additional information lipB mutant strain, grows well when supplemented with octanoate in place of lipoate Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.1.20 additional information Escherichia coli LplA potein attaches octanoate to the dehydrogenase and LipA protein then converts the octanoate to lipoate ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.60 Escherichia coli
-
-
-
2.8.1.8 Escherichia coli
-
-
-
6.3.1.20 Escherichia coli
-
-
-
6.3.1.20 Escherichia coli
-
 isoenzymes LipB, LplA
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.60 additional information lipoate-protein ligase attaches octanoate to the dehydrogenase subunit and sulfur insertion protein LipA then converts octanoate to lipoate. LipA acts on both octanoate and octanoyl-proteins Escherichia coli ?
-
 ?
2.8.1.8 protein N6-(octanoyl)lysine + sulfur + S-adenosyl-L-methionine octanoylated pyruvate dehydrogenase E2 domain Escherichia coli protein N6-(lipoyl)lysine + 2 L-methionine + 5'-deoxyadenosyl radical
-
 ?
6.3.1.20 ATP + octanoate + pyruvate dehydrogenase subunit E2 lipoate-protein ligase attaches octanoate to the dehydrogenase subunit and sulfur insertion protein LipA, then converts octanoate to lipoate. LipA acts on both octanoate and octanoyl-proteins Escherichia coli diphosphate + AMP + octanoyl-pyruvate dehydrogenase subunit E2
-
 ?
6.3.1.20 additional information LplA potein attaches octanoate to the dehydrogenase and LipA protein then converts the octanoate to lipoate Escherichia coli ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.60 LipA
-
 Escherichia coli
6.3.1.20 LPLA
-
 Escherichia coli