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Literature summary extracted from

  • Molestina, R.E.; Sinai, A.P.
    Detection of a novel parasite kinase activity at the Toxoplasma gondii parasitophorous vacuole membrane capable of phosphorylating host IkBa (2005), Cell. Microbiol., 7, 351-362.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.10 vacuolar membrane parasitophorous, PVM Toxoplasma gondii 5774
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 ATP + [IkappaBalpha protein] Toxoplasma gondii parasite IKKalpha, localized in parasitophorous vacuole membrane, activates mouse' intracellular NF-kappaB through phosphorylation of host IkappaBalpha at Ser32 and Ser36 in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex ADP + [IkappaBalpha phosphoprotein]
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?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Toxoplasma gondii
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RH strain in mouse embryonic fibroblast host MEF cells, wild-type and IKKalpha- or IKKbeta-deficient host cells
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 ATP + [GST-IkappaBalpha1-54 protein] recombinant substrate derived from mouse IkappaBalpha Toxoplasma gondii ADP + [GST-IkappaBalpha1-54 phosphoprotein]
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?
2.7.11.10 ATP + [IkappaB protein]
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Toxoplasma gondii ADP + [IkappaB phosphoprotein]
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?
2.7.11.10 ATP + [IkappaBalpha protein] parasite IKKalpha, localized in parasitophorous vacuole membrane, activates mouse' intracellular NF-kappaB through phosphorylation of host IkappaBalpha at Ser32 and Ser36 in early infection stage resulting in NF-kappaB nuclear translocation and subsequent gene expression independently from the host IKK complex Toxoplasma gondii ADP + [IkappaBalpha phosphoprotein]
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 IKK
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Toxoplasma gondii

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.10 ATP
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Toxoplasma gondii