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Literature summary extracted from

  • Keith, R.L.; Miller, Y.E.; Hudish, T.M.; Girod, C.E.; Sotto-Santiago, S.; Franklin, W.A.; Nemenoff, R.A.; March, T.H.; Nana-Sinkam, S.P.; Geraci, M.W.
    Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice (2004), Cancer Res., 64, 5897-5904.
    View publication on PubMed

Application

EC Number Application Comment Organism
5.3.99.4 medicine manipulation of prostaglandin production distal to cyclooxygenase significantly reduces lung carcinogenesis in a tobacco smoke exposure model Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.3.99.4 expression in alveolar and airway epithelial cells from Mus musculus Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.4 Prostaglandin H2 Rattus norvegicus
-
 Prostaglandin I2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.4 lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.4 Prostaglandin H2
-
 Rattus norvegicus Prostaglandin I2
-
 ?
5.3.99.4 prostaglandin H2
-
 Rattus norvegicus 6-keto prostaglandin F1-alpha
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.4 prostacyclin synthase
-
 Rattus norvegicus