Data extracted from this reference:
Application
2.4.2.12
pharmacology
enzyme is a potential target for development of anticancer drugs
Homo sapiens
Inhibitors
2.4.2.12
FK866
a highly specific noncompetitive inhibitor the enzyme, represents a novel mechanism for induction of tumor cell apoptosis, counteracted by nicotinic acid and nicotinamide
Homo sapiens
Localization
2.4.2.12
mitochondrion
Homo sapiens
5739
Natural Substrates/ Products (Substrates)
2.4.2.12
additional information
Homo sapiens
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis in tissues with a high demand for NAD+
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
key enzyme in the regulation of NAD+ biosynthesis from the natural precursor nicotinamide
nicotinamide D-ribonucleotide + diphosphate
?
Organism
Purification (Commentary)
2.4.2.12
partially frim K-562 leukemic cells
Homo sapiens
Source Tissue
2.4.2.12
Hep-G2 cell
liver carcinoma cell line
Homo sapiens
2.4.2.12
K-562 cell
leukemia cell line
Homo sapiens
Substrates and Products (Substrate)
2.4.2.12
additional information
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis in tissues with a high demand for NAD+
661421
Homo sapiens
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
661421
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
key enzyme in the regulation of NAD+ biosynthesis from the natural precursor nicotinamide
661421
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
?
Synonyms
2.4.2.12
NAPRT
Homo sapiens
Temperature Optimum [°C]
2.4.2.12
37
assay at
Homo sapiens
pH Optimum
2.4.2.12
8.8
assay at
Homo sapiens
Ki Value [mM]
2.4.2.12
0.0003
FK866
free enzyme
Homo sapiens
2.4.2.12
0.0004
FK866
enzyme-substrate complex
Homo sapiens
Application (protein specific)
2.4.2.12
pharmacology
enzyme is a potential target for development of anticancer drugs
Homo sapiens
Inhibitors (protein specific)
2.4.2.12
FK866
a highly specific noncompetitive inhibitor the enzyme, represents a novel mechanism for induction of tumor cell apoptosis, counteracted by nicotinic acid and nicotinamide
Homo sapiens
Ki Value [mM] (protein specific)
2.4.2.12
0.0003
FK866
free enzyme
Homo sapiens
2.4.2.12
0.0004
FK866
enzyme-substrate complex
Homo sapiens
Localization (protein specific)
2.4.2.12
mitochondrion
Homo sapiens
5739
Natural Substrates/ Products (Substrates) (protein specific)
2.4.2.12
additional information
Homo sapiens
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis in tissues with a high demand for NAD+
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
Homo sapiens
key enzyme in the regulation of NAD+ biosynthesis from the natural precursor nicotinamide
nicotinamide D-ribonucleotide + diphosphate
?
Purification (Commentary) (protein specific)
2.4.2.12
partially frim K-562 leukemic cells
Homo sapiens
Source Tissue (protein specific)
2.4.2.12
Hep-G2 cell
liver carcinoma cell line
Homo sapiens
2.4.2.12
K-562 cell
leukemia cell line
Homo sapiens
Substrates and Products (Substrate) (protein specific)
2.4.2.12
additional information
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis in tissues with a high demand for NAD+
661421
Homo sapiens
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
661421
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
?
2.4.2.12
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
key enzyme in the regulation of NAD+ biosynthesis from the natural precursor nicotinamide
661421
Homo sapiens
nicotinamide D-ribonucleotide + diphosphate
?
Temperature Optimum [°C] (protein specific)
2.4.2.12
37
assay at
Homo sapiens
pH Optimum (protein specific)
2.4.2.12
8.8
assay at
Homo sapiens