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Literature summary extracted from

  • Ghadessy, R.S.; Willets, J.M.; Kelly, E.
    G protein-coupled receptor kinase 6 (GRK6) selectively regulates endogenous secretin receptor responsiveness in NG108-15 cells (2003), Br. J. Pharmacol., 138, 660-670.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.15 transient overexpression of wild-type GRK2 in NG108-15 mouse neuroblastoma x rat glioma hybrid cells Bos taurus
2.7.11.16 transient overexpression of wild-types and dominant negative mutants of GRK5 and GRK6 in NG108-15 mouse neuroblastoma x rat glioma hybrid cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.15 additional information transient overexpression of wild-type GRK2 in NG108-15 mouse neuroblastoma x rat glioma hybrid cells leads to selective inhibition of A2 adenosine receptor responsiveness, but does not affect secretin-stimulated cyclic AMP accumulation Bos taurus
2.7.11.16 K215R site-directed mutagenesis, dominant negative mutants of GRK5 or GRK6, overexpression of mutant GRK6 or mutant GRK5 in NG108-15 mouse neuroblastoma x rat glioma hybrid cells results in selective increase in secretin-stimulated cyclic AMP response, the dominant negative mutant of GRK5 has no effect on cAMP response Homo sapiens
2.7.11.16 additional information transient overexpression of wild-type GRK6 in NG108-15 mouse neuroblastoma x rat glioma hybrid cells results in highly selective inhibition of secretin-stimulated cyclic AMP accumulation without afffecting the A2 adenosine receptor responsiveness to cAMP, while overexpression of wild-type GRK5 leads to a partly selective inhibition of secretin-stimulated cyclic AMP response and to inhibition of A2 adenosine receptor responsiveness Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 additional information Bos taurus GRK2 is involved in A2 adenosine receptor response to agonists ?
-
 ?
2.7.11.16 additional information Homo sapiens GRK5 and especially GRK6 have selective regulatory roles in cAMP accumulation response of the secretin receptor to agonists like beta-arrestin-1 or forskolin, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Bos taurus
-
-
-
2.7.11.16 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 additional information GRK2 is involved in A2 adenosine receptor response to agonists Bos taurus ?
-
 ?
2.7.11.16 additional information GRK5 and especially GRK6 have selective regulatory roles in cAMP accumulation response of the secretin receptor to agonists like beta-arrestin-1 or forskolin, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.15 G protein-coupled receptor kinase 2
-
 Bos taurus
2.7.11.15 GRK2
-
 Bos taurus
2.7.11.16 G protein-coupled receptor kinase 5
-
 Homo sapiens
2.7.11.16 G protein-coupled receptor kinase 6
-
 Homo sapiens
2.7.11.16 GRK5
-
 Homo sapiens
2.7.11.16 GRK6
-
 Homo sapiens