EC Number | Application | Comment | Organism |
---|---|---|---|
2.7.10.2 | drug development | PTKS are key targets for anticancer drug discovery | Homo sapiens |
2.7.10.2 | pharmacology | PTKS are key targets for anticancer drug discovery | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.10.2 | additional information | - |
additional information | kinetics | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.7.10.2 | cytoplasm | - |
Homo sapiens | 5737 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.10.2 | Mg2+ | essential, 2 Mg2+ are required, one Mg2+ binds to ATP as MgATP-, the other Mg2+ acts as an essential activator on the enzyme, whose binding is pH-sensitive between pH 6.0 and pH 7.0, M2 binding involves Glu236 and Asp332, binding structure, overview | Homo sapiens | |
2.7.10.2 | additional information | the ability of metal cations to interact with Csk correlates with a combination of ionic radius and the coordination number | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.10.2 | ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? | |
2.7.10.2 | additional information | Homo sapiens | PTKs are involved in cell signalling | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.10.2 | Homo sapiens | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.7.10.2 | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate | catalytic mechanism | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.10.2 | ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
2.7.10.2 | ATP + poly(Glu4-Tyr) | artificial substrate | Homo sapiens | ADP + poly(Glu4-Tyr)-L-tyrosine phosphate | - |
? | |
2.7.10.2 | ATP + [kdSrc kinase]-L-tyrosine | i.e. kinase-defective chicken Src mutant K295M | Homo sapiens | ADP + [kdSrc kinase]-L-tyrosine phosphate | - |
? | |
2.7.10.2 | additional information | PTKs are involved in cell signalling | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.10.2 | C-terminal Src kinase | - |
Homo sapiens |
2.7.10.2 | Csk | - |
Homo sapiens |
2.7.10.2 | More | Csk belongs to the Src kinase family | Homo sapiens |
2.7.10.2 | Protein tyrosine kinase | - |
Homo sapiens |
2.7.10.2 | PTK | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.10.2 | 30 | - |
assay at | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.10.2 | 8 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.10.2 | ATP | as MgATP- | Homo sapiens |