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Literature summary extracted from

  • Lin, X.; Ayrapetov, M.K.; Sun, G.
    Characterization of the interactions between the active site of a protein tyrosine kinase and a divalent metal activator (2005), BMC Biochem., 6, 25.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.10.2 drug development PTKS are key targets for anticancer drug discovery Homo sapiens
2.7.10.2 pharmacology PTKS are key targets for anticancer drug discovery Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.10.2 additional information
-
additional information kinetics Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.10.2 cytoplasm
-
Homo sapiens 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.10.2 Mg2+ essential, 2 Mg2+ are required, one Mg2+ binds to ATP as MgATP-, the other Mg2+ acts as an essential activator on the enzyme, whose binding is pH-sensitive between pH 6.0 and pH 7.0, M2 binding involves Glu236 and Asp332, binding structure, overview Homo sapiens
2.7.10.2 additional information the ability of metal cations to interact with Csk correlates with a combination of ionic radius and the coordination number Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine Homo sapiens
-
ADP + a [protein]-L-tyrosine phosphate
-
?
2.7.10.2 additional information Homo sapiens PTKs are involved in cell signalling ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.10.2 ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate catalytic mechanism Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine
-
Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
?
2.7.10.2 ATP + poly(Glu4-Tyr) artificial substrate Homo sapiens ADP + poly(Glu4-Tyr)-L-tyrosine phosphate
-
?
2.7.10.2 ATP + [kdSrc kinase]-L-tyrosine i.e. kinase-defective chicken Src mutant K295M Homo sapiens ADP + [kdSrc kinase]-L-tyrosine phosphate
-
?
2.7.10.2 additional information PTKs are involved in cell signalling Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 C-terminal Src kinase
-
Homo sapiens
2.7.10.2 Csk
-
Homo sapiens
2.7.10.2 More Csk belongs to the Src kinase family Homo sapiens
2.7.10.2 Protein tyrosine kinase
-
Homo sapiens
2.7.10.2 PTK
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.10.2 30
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.10.2 8
-
assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.2 ATP as MgATP- Homo sapiens