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Literature summary extracted from

  • Yuan, H.; Silverman, R.B.
    New substrates and inhibitors of gamma-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: Design, synthesis, and biological activity (2005), Bioorg. Med. Chem., 14, 1331-1338.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.19 1H-tetrazole-5-(alpha-vinyl-propanamine)
-
 Sus scrofa
2.6.1.19 4-aminohex-5-enoic acid
-
 Sus scrofa
2.6.1.19 tetrazole-5-(alpha-vinyl-propanamine)
-
 Sus scrofa
2.6.1.19 vigabatrin
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.19 2.3
-
 1H-tetrazole-5-ethanamine pH 8.5 Sus scrofa
2.6.1.19 2.3
-
 tetrazole-5-ethanamine at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa
2.6.1.19 2.4
-
 4-aminobutanoate pH 8.5 Sus scrofa
2.6.1.19 2.4
-
 1H-tetrazole-5-propanamine pH 8.5 Sus scrofa
2.6.1.19 2.4
-
 4-aminobutanoate at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa
2.6.1.19 2.4
-
 tetrazole-5-propanamine at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa
2.6.1.19 8
-
 1H-tetrazole-5-butanamine pH 8.5 Sus scrofa
2.6.1.19 8
-
 tetrazole-5-butanamine at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.19 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.19 brain
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.19 1H-tetrazole-5-butanamine + 2-oxoglutarate
-
 Sus scrofa (1H-tetrazol-5-yl)-butyraldehyde + L-glutamate
-
 ?
2.6.1.19 1H-tetrazole-5-ethanamine + 2-oxoglutarate
-
 Sus scrofa (1H-tetrazol-5-yl)-acetaldehyd + L-glutamate
-
 ?
2.6.1.19 1H-tetrazole-5-propanamine + 2-oxoglutarate
-
 Sus scrofa (1H-tetrazol-5-yl)-propionaldehyde + L-glutamate
-
 ?
2.6.1.19 4-aminobutanoate + 2-oxoglutarate
-
 Sus scrofa 4-oxobutanoate + L-glutamate
-
 ?
2.6.1.19 tetrazole-5-butanamine + 2-oxoglutarate
-
 Sus scrofa ?
-
 ?
2.6.1.19 tetrazole-5-ethanamine + 2-oxoglutarate
-
 Sus scrofa ?
-
 ?
2.6.1.19 tetrazole-5-propanamine + 2-oxoglutarate
-
 Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.19 GABA-AT
-
 Sus scrofa
2.6.1.19 gamma-aminobutyric acid aminotransferase
-
 Sus scrofa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.6.1.19 0.26
-
 1H-tetrazole-5-ethanamine pH 8.5 Sus scrofa
2.6.1.19 0.265
-
 tetrazole-5-ethanamine at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa
2.6.1.19 0.477
-
 tetrazole-5-propanamine at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa
2.6.1.19 0.48
-
 1H-tetrazole-5-propanamine pH 8.5 Sus scrofa
2.6.1.19 0.69
-
 1H-tetrazole-5-butanamine pH 8.5 Sus scrofa
2.6.1.19 0.693
-
 tetrazole-5-butanamine at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa
2.6.1.19 0.81
-
 4-aminobutanoate pH 8.5 Sus scrofa
2.6.1.19 0.817
-
 4-aminobutanoate at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.19 pyridoxal 5'-phosphate dependent Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.19 2.6
-
 4-aminohex-5-enoic acid
-
 Sus scrofa
2.6.1.19 2.6
-
 vigabatrin pH 8.5 Sus scrofa
2.6.1.19 5.6
-
 tetrazole-5-(alpha-vinyl-propanamine)
-
 Sus scrofa
2.6.1.19 5.6
-
 1H-tetrazole-5-(alpha-vinyl-propanamine) pH 8.5 Sus scrofa