EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.7.1.74 | crystal structure model construction, using the crystal structure of deoxyguanosine kinase, EC 2.7.1.113, as a template, for docking simulations of enzyme with purine nucleosides and analogues, overview | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.74 | Mg2+ | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.74 | ATP + 2'-deoxycytidine | Homo sapiens | - |
ADP + 2'-deoxycytidine 5'-phosphate | - |
? | |
2.7.1.74 | additional information | Homo sapiens | 5'-phosphorylation of is a crucial step in metabolic activation of anticancer and antiviral nucleoside antimetabolites, such as cladribine, gemcitabine, cytarabine, and lamivudine | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.74 | Homo sapiens | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.7.1.74 | NTP + deoxycytidine = NDP + dCMP | active site structure, substrate binding structure simulation and analysis | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.74 | ATP + 2',2'-difluorodeoxycytidine | i.e. gemcitabine | Homo sapiens | ADP + 2',2'-difluorodeoxycytidine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + 2'-deoxycytidine | - |
Homo sapiens | ADP + 2'-deoxycytidine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + 2-chloro-2'-deoxyadenosine | i.e. cladribine | Homo sapiens | ADP + 2-chloro-2'-deoxyadenosine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + cytarabine | - |
Homo sapiens | ADP + cytarabine 5'-phosphate | - |
? | |
2.7.1.74 | ATP + lamivudine | - |
Homo sapiens | ADP + lamivudine 5'-phosphate | - |
? | |
2.7.1.74 | additional information | 5'-phosphorylation of is a crucial step in metabolic activation of anticancer and antiviral nucleoside antimetabolites, such as cladribine, gemcitabine, cytarabine, and lamivudine | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.74 | dCK | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.74 | ATP | - |
Homo sapiens |