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Literature summary extracted from

  • Kim, J.W.; Kim, Y.W.; Inagaki, Y.; Hwang, Y.A.; Mitsutake, S.; Ryu, Y.W.; Lee, W.K.; Ha, H.J.; Park, C.S.; Igarashi, Y.
    Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases (2005), Bioorg. Med. Chem., 13, 3475-3485.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.91 transient expression of HA-tagged isozymes SphK1 and SphK2 in CHO-K1 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.91 (2R)-2-amino-4-(4-octylphenyl)butan-1-ol i.e. (R)-2-amino-4-(4-octylphenyl)butan-1-ol, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 (2R,3S)-3-amino-4-morpholin-4-yl-1-phenylbutan-2-ol i.e. (2R,3S)-3-amino-4-morpholino-1-phenylbutan-2-ol, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 (2S,3R)-2-amino-4-(4-octylphenyl)butane-1,3-diol i.e. (2S,3R)-2-amino-4-(4-octylphenyl)butane-1,3-diol, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 (2S,3S)-2-amino-4-(4-octylphenyl)butane-1,3-diol i.e. (2S,3S)-2-amino-4-(4-octylphenyl)butane-1,3-diol, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 additional information inhibitors of isozyme SphK2 are cytotoxic, overview, inhibitory potency of the synthetic sphingosine analogues on isozymes SphK1 and SphK2, overview Homo sapiens
2.7.1.91 N,N-dimethylsphingosine inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 N-((2S,3S)-1,3-dihydroxy-4-phenylbutan-2-yl)tridecanamide i.e. N-((2S,3S)-1,3-dihydroxy-4-phenylbutan-2-yl)tridecanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 N-[(1R)-1-(hydroxymethyl)-3-phenylpropyl]tridecanamide i.e. N-((R)-1-hydroxy-4-phenylbutan-2-yl)tridecanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 N-[(1R)-3-phenyl-1-(pyrrolidin-1-ylmethyl)propyl]decanamide i.e. N-((R)-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)decanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 N-[(1S)-1-methyl-3-phenylpropyl]hexadecanamide i.e. N-((R)-1-hydroxy-4-phenylbutan-2-yl)palmitamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]hexadecanamide i.e. N-((2S,3R)-1,3-dihydroxy-4-phenylbutan-2-yl)palmitamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]tridecanamide i.e. N-((2S,3R)-1,3-dihydroxy-4-phenylbutan-2-yl)tridecanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 N-[(1S,2R)-2-hydroxy-3-phenyl-1-(pyrrolidin-1-ylmethyl)propyl]octadecanamide i.e. N-((2S,3R)-3-hydroxy-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)stearamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 N-[(1S,2S)-2-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]hexadecanamide i.e. N-((2S,3S)-1,3-dihydroxy-4-phenylbutan-2-yl)palmitamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 N-[(1S,2S)-2-hydroxy-1-(morpholin-4-ylmethyl)-3-phenylpropyl]decanamide i.e. N-((2S,3S)-3-hydroxy-1-morpholino-4-phenylbutan-2-yl)decanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 N-[(1S,2S)-2-hydroxy-3-phenyl-1-(pyrrolidin-1-ylmethyl)propyl]decanamide i.e. N-((2S,3S)-3-hydroxy-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)decanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens
2.7.1.91 N-[(1S,2S)-2-hydroxy-3-phenyl-1-(pyrrolidin-1-ylmethyl)propyl]octadecanamide i.e. N-((2S,3S)-3-hydroxy-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)stearamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.91 Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.91 ATP + sphingosine Homo sapiens
-
ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a mediator in diverse biological processes such as cell differentiation, proliferation, motility, and apoptosis ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.91 Homo sapiens
-
isozymes SphK1 and SphK2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.91 platelet
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.91 ATP + phytosphingosine low activity Homo sapiens ADP + phytosphingosine 1-phosphate
-
?
2.7.1.91 ATP + sphingosine
-
Homo sapiens ADP + sphingosine 1-phosphate
-
?
2.7.1.91 ATP + sphingosine
-
Homo sapiens ADP + sphingosine 1-phosphate sphingosine 1-phosphate is a mediator in diverse biological processes such as cell differentiation, proliferation, motility, and apoptosis ?
2.7.1.91 additional information FYT720 is no substrate of isozymes SphK1 and SphK2 Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.91 sphinganine kinase
-
Homo sapiens
2.7.1.91 SPHK
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.91 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.91 7.5
-
assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.91 ATP
-
Homo sapiens