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Literature summary extracted from

  • Nam, N.H.; Lee, S.; Ye, G.; Sun, G.; Parang, K.
    ATP-phosphopeptide conjugates as inhibitors of Src tyrosine kinases (2004), Bioorg. Med. Chem., 12, 5753-5766.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 AcpYEEI ATP-phosphopeptide conjugate Homo sapiens
2.7.10.2 ATP-1,13-Trioxa-SA-phospho-Tyr-g-p-azido-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
2.7.10.2 ATP-1,13-Trioxa-Suc-phospho-Tyr-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
2.7.10.2 ATP-1,8-Diam-Suc-1,8-Diam-Suc-phospho-Tyr-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
2.7.10.2 ATP-11-Aund-phospho-Tyr-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
2.7.10.2 ATP-6-Ahex-phospho-Tyr-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
2.7.10.2 ATP-8-Aoct-phospho-Tyr-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
2.7.10.2 ATP-beta-Ala-phospho-Tyr-Glu-Glu-Ile-OH inhibition of SH2 domain tyrosine protein kinases Homo sapiens
2.7.10.2 ATP-gamma-S
-
 Homo sapiens
2.7.10.2 additional information synthesis, inhibitory potency, and mechanism of ATP-SH2-domain-derived phosphopeptide conjugates with short or long linkers binding at the ATP-binding site, structure-activity-relationship, overview Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.10.2 Mg2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens P12931
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + poly(Glu4-Tyr)
-
 Homo sapiens ADP + poly(Glu4-Tyr)-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Lck
-
 Homo sapiens
2.7.10.2 Protein tyrosine kinase
-
 Homo sapiens
2.7.10.2 PTK
-
 Homo sapiens
2.7.10.2 Src
-
 Homo sapiens
2.7.10.2 Src tyrosine kinase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.10.2 30
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.2 ATP structure-activity-relationship, overview Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.10.2 0.0017
-
 ATP-1,13-Trioxa-Suc-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
2.7.10.2 0.0026
-
 ATP-1,13-Trioxa-SA-phospho-Tyr-g-p-azido-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
2.7.10.2 0.0101
-
 ATP-beta-Ala-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
2.7.10.2 0.0115
-
 ATP-6-Ahex-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
2.7.10.2 0.0141
-
 ATP-8-Aoct-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
2.7.10.2 0.0158
-
 ATP-11-Aund-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
2.7.10.2 0.0161
-
 ATP-1,8-Diam-Suc-1,8-Diam-Suc-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Src Homo sapiens
2.7.10.2 0.0253
-
 ATP-1,13-Trioxa-Suc-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
2.7.10.2 0.03
-
 ATP-1,13-Trioxa-SA-phospho-Tyr-g-p-azido-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
2.7.10.2 0.0355
-
 ATP-8-Aoct-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
2.7.10.2 0.0426
-
 ATP-1,8-Diam-Suc-1,8-Diam-Suc-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
2.7.10.2 0.0455
-
 ATP-6-Ahex-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
2.7.10.2 0.0472
-
 ATP-11-Aund-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
2.7.10.2 0.0571
-
 ATP-gamma-S 30°C, Src Homo sapiens
2.7.10.2 0.1078
-
 ATP-beta-Ala-phospho-Tyr-Glu-Glu-Ile-OH 30°C, Lck Homo sapiens
2.7.10.2 0.1414
-
 AcpYEEI 30°C, Src Homo sapiens