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Literature summary extracted from

  • Hediger, M.E.
    Design, synthesis, and evaluation of aza inhibitors of chorismate mutase (2004), Bioorg. Med. Chem., 12, 4995-5010.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.4.99.5
-
Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.5 (1R,2S,3S,5S,7S)-10-hydroxy-3-oxo-2-oxa-5-azatricyclo[4.3.1.1(4,8)]undecane-8-carboxylate does not display tighter binding to the enzyme than the native substrate chorismate or greater inhibitory action than the ether analogue Escherichia coli
5.4.99.5 (1R,3R,5S,8R)-2-azatricyclo[3.3.1.0(1,8)]-non-6-ene-3,5-dicarboxylate exo arizidine analogue, no time-dependent loss of activity is observed in the presence of this potentially reactive aza inhibitor Escherichia coli
5.4.99.5 (1R,3R,5S,8S)-8-hydroxy-2-azabicyclo[3.3.1]non-6-ene-3,5-dicarboxylate does not display tighter binding to the enzyme than the native substrate chorismate or greater inhibitory action than the ether analogue Escherichia coli
5.4.99.5 (1R,3S,5S,8S)-8-hydroxy-2-azabicyclo[3.3.1]non-6-ene-3,5-dicarboxylate does not display tighter binding to the enzyme than the native substrate chorismate or greater inhibitory action than the ether analogue Escherichia coli
5.4.99.5 (1S,4S,6R,8S,10S)-3-oxo-5-aza-2-oxa-tetracyclo[4.3.1.(4,8).0(6,10)]undecane-8-carboxylate tetracyclic lactone, no time-dependent loss of activity is observed in the presence of this potentially reactive aza inhibitor Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.99.5 Chorismate Escherichia coli
-
Prephenate
-
?
5.4.99.5 Chorismate Escherichia coli JFM-30
-
Prephenate
-
?

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.5 Escherichia coli
-
-
-
5.4.99.5 Escherichia coli JFM-30
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.4.99.5
-
Escherichia coli

Storage Stability

EC Number Storage Stability Organism
5.4.99.5 -78°C, 100 mM N-ethylmorpholine, 1.0 mM dithioerythritol, 1.0 mM N-ethylene-diaminetetraacetic acid, 21 mM trisodium citrate, 10% (v/v) glycerol in doubly distilled water adjusted to pH 7.0 with concentrated HCl Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.5 Chorismate
-
Escherichia coli Prephenate
-
?
5.4.99.5 Chorismate
-
Escherichia coli JFM-30 Prephenate
-
?

Synonyms

EC Number Synonyms Comment Organism
5.4.99.5 chorismate mutase
-
Escherichia coli