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Literature summary extracted from

  • Uchiyama, Y.; Tagami, J.; Kamisuki, S.; Kasai, N.; Oshige, M.; Chiku, H.; Ibe, S.; Koiwai, O.; Sugawara, F.; Sakaguchi, K.
    Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin (2005), Biochim. Biophys. Acta, 1725, 298-304.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.31 Baicalin competitive versus the DNA primer and non-competitive versus the dNTP substrate, IC50: 0.0186 mM Homo sapiens
2.7.7.31 genistein competitive versus the DNA primer and non-competitive versus the dNTP substrate, IC50: 0.0287 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.31 Homo sapiens
-
 recombinant
-

Synonyms

EC Number Synonyms Comment Organism
2.7.7.31 TdT
-
 Homo sapiens
2.7.7.31 terminal deoxyribonucleotidyltransferase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.7.31 0.00981
-
 Baicalin versus dNTP substrate Homo sapiens
2.7.7.31 0.0152
-
 Baicalin versus DNA primer Homo sapiens
2.7.7.31 0.0231
-
 genistein versus DNA primer Homo sapiens
2.7.7.31 0.0338
-
 genistein versus dNTP substrate Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.7.31 0.0186
-
 competitive versus the DNA primer and non-competitive versus the dNTP substrate, IC50: 0.0186 mM Homo sapiens Baicalin
2.7.7.31 0.0287
-
 competitive versus the DNA primer and non-competitive versus the dNTP substrate, IC50: 0.0287 mM Homo sapiens genistein