EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.10.2 | additional information | Tec family tyrosine kinase is activated by tyrosine phosphorylation | Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
2.7.10.2 | expression of SH3 domains of Tec tyrosine kinase family members in Escherichia coli strain XL-1 Blue as GST-fusion proteins, expression of His-tagged SH3 domain from Btk in Spodoptera frugiperda Sf9 cells using a baculovirus expression system, overview | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.10.2 | Y223A | site-directed mutagenesis of the SH3 domain tyrosine of Btk, the mutant is not phosphorylated | Homo sapiens |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.10.2 | Mg2+ | - |
Homo sapiens | |
2.7.10.2 | Mn2+ | - |
Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.10.2 | ATP + a [protein]-L-tyrosine | Homo sapiens | - |
ADP + a [protein]-L-tyrosine phosphate | - |
? | |
2.7.10.2 | additional information | Homo sapiens | Tec family tyrosine kinases play a central role in hematopoietic cellular signaling | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.10.2 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.7.10.2 | phosphoprotein | Tec family tyrosine kinase is activated by tyrosine phosphorylation in the activation loop, a transphosphorylation mechanism is used for further acivation in the SH3 domain, specific phosphorylation at conserved residues, i.e. Tyr223 of Btk, Tyr180 of Itk, Tyr215 of Bmx, and Tyr206 of Tec, autophosphorylation or phosphorylation by family members, but not of other non-family SH3-domains, proline-rich consensus sequences, overview | Homo sapiens |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.10.2 | recombinant GST-fusion-SH3 domains of Tec tyrosine kinase family members from Escherichia coli strain XL-1 Blue, recombinant His-tagged Btk SH3 domain from Sf9 cells, affinity chromatography | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.10.2 | ATP + a [protein]-L-tyrosine | - |
Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
2.7.10.2 | ATP + a [protein]-L-tyrosine | enzymes of the Tec tyrosine kinase family phosphorylate themselves or other family members | Homo sapiens | ADP + a [protein]-L-tyrosine phosphate | - |
? | |
2.7.10.2 | additional information | Tec family tyrosine kinases play a central role in hematopoietic cellular signaling | Homo sapiens | ? | - |
? | |
2.7.10.2 | additional information | site specificity of tyrosine phosphorylation by Tec family members, overview | Homo sapiens | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.7.10.2 | More | SH3 domain structures, ligand binding structures | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.10.2 | Bmx | - |
Homo sapiens |
2.7.10.2 | Bruton's tyrosine kinase | - |
Homo sapiens |
2.7.10.2 | Btk | - |
Homo sapiens |
2.7.10.2 | Itk | - |
Homo sapiens |
2.7.10.2 | More | Tec, Btk, Itk, and Bmx are members of the Tec tyrosine kinase family | Homo sapiens |
2.7.10.2 | Tec | - |
Homo sapiens |
2.7.10.2 | Tec family tyrosine kinase | - |
Homo sapiens |
2.7.10.2 | TFK | - |
Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.10.2 | 7.5 | - |
assay at | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.10.2 | ATP | - |
Homo sapiens |