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Literature summary extracted from

  • Lue, S.W.; Kelley, S.O.
    An aminoacyl-tRNA synthetase with a defunct editing site (2005), Biochemistry, 44, 3010-3016.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.1.1.4 0.015
-
 L-leucine pH 7.5, 37°C Escherichia coli
6.1.1.4 0.13
-
 L-leucine pH 7.5, 37°C Homo sapiens
6.1.1.4 0.25
-
 L-isoleucine pH 7.5, 37°C Escherichia coli
6.1.1.4 14
-
 L-isoleucine pH 7.5, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.1.1.4 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.4 Escherichia coli
-
-
-
6.1.1.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.4 ATP + L-isoleucine + tRNALeu the ratio of turnover number to KM-value for L-leucine is 1600fold higher than the ratio observed for L-isoleucine Escherichia coli AMP + diphosphate + L-isoleucyl-tRNALeu
-
 ?
6.1.1.4 ATP + L-isoleucine + tRNALeu the ratio of turnover number to KM-value for L-leucine is 3000fold higher than the ratio observed for L-isoleucine Homo sapiens AMP + diphosphate + L-isoleucyl-tRNALeu
-
 ?
6.1.1.4 ATP + L-leucine + tRNALeu
-
 Escherichia coli AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
6.1.1.4 ATP + L-leucine + tRNALeu
-
 Homo sapiens AMP + diphosphate + L-leucyl-tRNALeu
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.4 hs mt LeuRS
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.1.1.4 0.07
-
 L-isoleucine pH 7.5, 37°C Homo sapiens
6.1.1.4 0.1
-
 L-isoleucine pH 7.5, 37°C Escherichia coli
6.1.1.4 2
-
 L-leucine pH 7.5, 37°C Homo sapiens
6.1.1.4 11
-
 L-leucine pH 7.5, 37°C Escherichia coli