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Literature summary extracted from

  • Gulick, A.M.; Lu, X.; Dunaway-Mariano, D.
    Crystal structure of 4-chlorobenzoate:CoA ligase/synthetase in the unliganded and aryl substrate-bound states (2004), Biochemistry, 43, 8670-8679.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.2.1.33 hanging drop vapor diffusion method, 1.0 and 2.2 A. Crystal structures of the enzyme both in the unliganded state and bound to 4-chlorobenzoate. The space group is P3(1)21 or P3(2)21 with a = b = 129.3 A, c = 71.5 A Alcaligenes sp.

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.33 4-Chlorobenzoate + CoA + ATP Alcaligenes sp. the enzyme catalyzes the synthesis of 4-chlorobenzoyl-CoA, the first step in the 4-chlorobenzoate degradation pathway in 4-chlorobenzoate-degrading bacteria 4-Chlorobenzoyl-CoA + AMP + diphosphate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.33 Alcaligenes sp.
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.2.1.33
-
 Alcaligenes sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.33 4-Chlorobenzoate + CoA + ATP the enzyme catalyzes the synthesis of 4-chlorobenzoyl-CoA, the first step in the 4-chlorobenzoate degradation pathway in 4-chlorobenzoate-degrading bacteria Alcaligenes sp. 4-Chlorobenzoyl-CoA + AMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.33 CBAL
-
 Alcaligenes sp.
6.2.1.33 chlorobenzoate:CoA ligase
-
 Alcaligenes sp.