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Literature summary extracted from

  • Vigil, D.; Blumenthal, D.K.; Brown, S.; Taylor, S.S.; Trewhella, J.
    Differential effects of substrate on type I and type II PKA holoenzyme dissociation (2004), Biochemistry, 43, 5629-5636.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.11 cAMP dependent on, activates the enzyme by partly dissociating the regulatory and the catalytic subunits, determination and analysis of the mechanism, the substrate plays a differential role in activation of type I versus type II holoenzyme Bos taurus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.11 distinct expression of catalytic subunit C, regulatory subunit RIalpha, and regulatory subunit RIIbeta in Escherichia coli strain 222 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.11 Mg2+
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Bos taurus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.11.11 ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate activation mechanism Bos taurus
a

Renatured (Commentary)

EC Number Renatured (Comment) Organism
2.7.11.11 recombinant catalytic subunit C, regulatory subunit RIalpha, and regulatory subunit RIIbeta from Escherichia coli strain 222 by cAMP-affinity chromatography, gel filtration, and dialysis Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + Kemptide catalytic subunit C Bos taurus ADP + Kemptide phosphate
-
 ?
2.7.11.11 additional information substrates have differential effects on type I and type II PKA holoenzyme dissociation, the isolated catalytic subunit is catalytically active Bos taurus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.11 More substrates have differential effects on type I and type II PKA holoenzyme dissociation, X-ray scattering measurements, overview Bos taurus

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 protein kinase A
-
 Bos taurus
2.7.11.11 type I PKA
-
 Bos taurus
2.7.11.11 type II PKA
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Bos taurus