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Literature summary extracted from

  • Nakamura, Y.; Kotite, L.; Gan, Y.; Spencer, T.A.; Fielding, C.J.; Fielding, P.E.
    Molecular mechanism of reverse cholesterol transport: reaction of pre-beta-migrating high-density lipoprotein with plasma lecithin/cholesterol acyltransferase (2004), Biochemistry, 43, 14811-14820.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 apolipoprotein A-I distribution in HDL, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.43 4-(2-aminoethyl)benzenesulfonylfluoride complete inhibition at 10 mM of the activity in plasma Homo sapiens
2.3.1.43 cholesteryl ester transfer protein 56% inhibition of the activity in plasma Homo sapiens
2.3.1.43 DTNB 83% inhibition at 1.4 mM of the activity in plasma Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.43 additional information
-
 enzyme forms higher aggregates with HDL and apolipoprotein A-I in plasma, overview Homo sapiens
2.3.1.43 67000
-
 x * 67000, native enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 additional information Homo sapiens enzyme forms higher aggregates with HDL and apolipoprotein A-I in plasma, esterification of cholesterol and binding to cholesteryl ester transfer protein are required for reverse cholesterol transport from peripheral cells to plasma ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 plasma
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.43 additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 additional information enzyme forms higher aggregates with HDL and apolipoprotein A-I in plasma, esterification of cholesterol and binding to cholesteryl ester transfer protein are required for reverse cholesterol transport from peripheral cells to plasma Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.43 ? x * 67000, native enzyme, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Homo sapiens
2.3.1.43 lecithin/cholesterol acyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.43 37
-
 assay at Homo sapiens