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Literature summary extracted from

  • Komoto, J.; Yamada, T.; Takata, Y.; Konishi, K.; Ogawa, H.; Gomi, T.; Fujioka, M.; Takusagawa, F.
    Catalytic mechanism of guanidinoacetate methyltransferase: crystal structures of guanidinoacetate methyltransferase ternary complexes (2004), Biochemistry, 43, 14385-14394.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.1.1.2 in complex with S-adenosylhomocysteine and guanidinoacetate, and in complex with S-adenosyl-homocysteine and guanidine Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.2 E45D decrease in kcat-value, increase in Km-value of S-adenosyl-L-methionine Rattus norvegicus
2.1.1.2 E45Q decrease in kcat-value, increase in Km-value of S-adenosyl-L-methionine Rattus norvegicus
2.1.1.2 E45S no residual activity Rattus norvegicus
2.1.1.2 Y221F decrease in kcat-value Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.2 guanidine
-
Rattus norvegicus
2.1.1.2 S-adenosylhomocysteine
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.1.1.2 0.002
-
S-adenosyl-L-methionine wild-type Rattus norvegicus
2.1.1.2 0.0042
-
S-adenosyl-L-methionine mutant E45D Rattus norvegicus
2.1.1.2 0.0088
-
S-adenosyl-L-methionine mutant E45Q Rattus norvegicus
2.1.1.2 0.013
-
Guanidinoacetate mutant E45Q Rattus norvegicus
2.1.1.2 0.022
-
Guanidinoacetate mutant E45D Rattus norvegicus
2.1.1.2 0.024
-
S-adenosyl-L-methionine mutant Y221F Rattus norvegicus
2.1.1.2 0.05
-
Guanidinoacetate wild-type Rattus norvegicus
2.1.1.2 2.3
-
Guanidinoacetate mutant Y221F Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.2 Rattus norvegicus P10868 recombinant protein
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.1.1.2 S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine mechanism Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.2 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.2 S-adenosyl-L-methionine + guanidinoacetate
-
Rattus norvegicus S-adenosyl-L-homocysteine + creatine
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.2 GAMT
-
Rattus norvegicus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.1.1.2 1
-
S-adenosyl-L-methionine mutant E45Q Rattus norvegicus
2.1.1.2 2.1
-
S-adenosyl-L-methionine mutant Y221F Rattus norvegicus
2.1.1.2 2.4
-
S-adenosyl-L-methionine mutant E45D Rattus norvegicus
2.1.1.2 3.8
-
S-adenosyl-L-methionine wild-type Rattus norvegicus