EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.1.1.2 | in complex with S-adenosylhomocysteine and guanidinoacetate, and in complex with S-adenosyl-homocysteine and guanidine | Rattus norvegicus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.1.1.2 | E45D | decrease in kcat-value, increase in Km-value of S-adenosyl-L-methionine | Rattus norvegicus |
2.1.1.2 | E45Q | decrease in kcat-value, increase in Km-value of S-adenosyl-L-methionine | Rattus norvegicus |
2.1.1.2 | E45S | no residual activity | Rattus norvegicus |
2.1.1.2 | Y221F | decrease in kcat-value | Rattus norvegicus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.2 | guanidine | - |
Rattus norvegicus | |
2.1.1.2 | S-adenosylhomocysteine | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.2 | 0.002 | - |
S-adenosyl-L-methionine | wild-type | Rattus norvegicus | |
2.1.1.2 | 0.0042 | - |
S-adenosyl-L-methionine | mutant E45D | Rattus norvegicus | |
2.1.1.2 | 0.0088 | - |
S-adenosyl-L-methionine | mutant E45Q | Rattus norvegicus | |
2.1.1.2 | 0.013 | - |
Guanidinoacetate | mutant E45Q | Rattus norvegicus | |
2.1.1.2 | 0.022 | - |
Guanidinoacetate | mutant E45D | Rattus norvegicus | |
2.1.1.2 | 0.024 | - |
S-adenosyl-L-methionine | mutant Y221F | Rattus norvegicus | |
2.1.1.2 | 0.05 | - |
Guanidinoacetate | wild-type | Rattus norvegicus | |
2.1.1.2 | 2.3 | - |
Guanidinoacetate | mutant Y221F | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.2 | Rattus norvegicus | P10868 | recombinant protein | - |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.1.1.2 | S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine | mechanism | Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.2 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.2 | S-adenosyl-L-methionine + guanidinoacetate | - |
Rattus norvegicus | S-adenosyl-L-homocysteine + creatine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.2 | GAMT | - |
Rattus norvegicus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.2 | 1 | - |
S-adenosyl-L-methionine | mutant E45Q | Rattus norvegicus | |
2.1.1.2 | 2.1 | - |
S-adenosyl-L-methionine | mutant Y221F | Rattus norvegicus | |
2.1.1.2 | 2.4 | - |
S-adenosyl-L-methionine | mutant E45D | Rattus norvegicus | |
2.1.1.2 | 3.8 | - |
S-adenosyl-L-methionine | wild-type | Rattus norvegicus |