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Literature summary extracted from

  • Mann, S.; Marquet, A.; Ploux, O.
    Inhibition of 7,8-diaminopelargonic acid aminotransferase by amiclenomycin and analogues (2005), Biochem. Soc. Trans., 33, 802-805.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.6.1.62 pharmacology enzyme is a potential drug target in tuberculosis treatment Mycobacterium tuberculosis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.62 overexpression as mostly insoluble, N-terminally His6-tagged enzyme in Escherichia coli Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.62 8-Amino-7-oxononanoate
-
Escherichia coli
2.6.1.62 amiclenomycin and analogues Mycobacterium tuberculosis
2.6.1.62 cis-amiclenomycin and analogues, overview, irreversible inactivation, kinact. 0.4 min-1, little or no inhibition by the trans-compound, overview Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.62 additional information
-
additional information kinetics Escherichia coli
2.6.1.62 0.0012
-
8-Amino-7-oxononanoate native enzyme Escherichia coli
2.6.1.62 0.2
-
S-adenosyl-L-methionine native enzyme Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate Escherichia coli involved in the biosynthesis of biotin S-adenosyl-4-methylthio-2-oxobutanoate + (7S,8R)-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate Mycobacterium tuberculosis involved in the biosynthesis of biotin S-adenosyl-4-methylthio-2-oxobutanoate + (7S,8R)-diaminononanoate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.62 Escherichia coli
-
-
-
2.6.1.62 Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.62 recombinant soluble N-terminally His6-tagged enzyme from Escherichia coli by nickel affinity chromatography Mycobacterium tuberculosis

Reaction

EC Number Reaction Comment Organism Reaction ID
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate structural basis for reaction mechanism Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate
-
Mycobacterium tuberculosis S-adenosyl-4-methylthio-2-oxobutanoate + (7S,8R)-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate involved in the biosynthesis of biotin Escherichia coli S-adenosyl-4-methylthio-2-oxobutanoate + (7S,8R)-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate involved in the biosynthesis of biotin Mycobacterium tuberculosis S-adenosyl-4-methylthio-2-oxobutanoate + (7S,8R)-diaminononanoate
-
?
2.6.1.62 S-adenosyl-L-methionine + 8-amino-7-oxononanoate first half-reaction is reversible, the second one is irreversible Escherichia coli S-adenosyl-4-methylthio-2-oxobutanoate + (7S,8R)-diaminononanoate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.62 7,8-diaminopelargonic acid aminotransferase
-
Escherichia coli
2.6.1.62 7,8-diaminopelargonic acid aminotransferase
-
Mycobacterium tuberculosis
2.6.1.62 DAPA AT
-
Escherichia coli
2.6.1.62 DAPA AT
-
Mycobacterium tuberculosis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.6.1.62 0.08
-
S-adenosyl-L-methionine recombinant enzyme Escherichia coli
2.6.1.62 0.13
-
S-adenosyl-L-methionine native enzyme Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.62 pyridoxal 5'-phosphate dependent on Escherichia coli
2.6.1.62 pyridoxal 5'-phosphate dependent on Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.62 additional information
-
additional information inactivation kinetics Escherichia coli
2.6.1.62 0.002
-
amiclenomycin native enzyme Escherichia coli
2.6.1.62 0.025
-
8-Amino-7-oxononanoate native enzyme Escherichia coli