Literature summary extracted from

Wang, X.; Song, K.S.; Guo, Q.X.; Tian, W.X.
The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase (2003), Biochem. Pharmacol., 66, 2039-2047.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.1.85	(+)-catechin	50% inhibition of overall enzyme reaction at 1.6 mM, 50% inhibition of ketoacyl reduction reaction at 7.4 mM	Gallus gallus
2.3.1.85	(-)-epicatechin	50% inhibition of overall enzyme reaction at 3.8 mM, 50% inhibition of ketoacyl reduction reaction at 9.38 mM	Gallus gallus
2.3.1.85	(-)-epicatechin gallate	50% inhibition of overall enzyme reaction at 0.042 mM, 50% inhibition of ketoacyl reduction reaction at 0.068 mM, two-step inhibition mechanism with reversible initial inhibition and irreversible subsequent inactivation	Gallus gallus
2.3.1.85	(-)-epigallocatechin gallate	0.5 mM, 20% residual activity, 50% inhibition of overall enzyme reaction at 0.052 mM, 50% inhibition of ketoacyl reduction reaction at 0.1 mM	Gallus gallus
2.3.1.85	3,4-dihydroxybenzoic acid	50% inhibition of overall enzyme reaction at 9.0 mM, 50% inhibition of ketoacyl reduction reaction at 30 mM	Gallus gallus
2.3.1.85	catechol	50% inhibition of overall enzyme reaction at 7.4 mM, 50% inhibition of ketoacyl reduction reaction at 21 mM	Gallus gallus
2.3.1.85	gallic acid	50% inhibition of overall enzyme reaction at 21 mM, 50% inhibition of ketoacyl reduction reaction at 26 mM	Gallus gallus
2.3.1.85	propyl gallate	50% inhibition of overall enzyme reaction at 0.5 mM, 50% inhibition of ketoacyl reduction reaction at 1.4 mM	Gallus gallus
2.3.1.85	propyl p-hydroxylbenzoate	50% inhibition of overall enzyme reaction at 1.1 mM, 50% inhibition of ketoacyl reduction reaction at 2.6 mM	Gallus gallus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.85	Gallus gallus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.3.1.85	liver	-	Gallus gallus	-

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Release 2023.1 (January 2023)